Evidence map›Paper›PMID 18387498›Full record

SynthesisClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2008

Hepatitis C and non-Hodgkin lymphoma among 4784 cases and 6269 controls from the International Lymphoma Epidemiology Consortium.

Silvia de Sanjose, Yolanda Benavente, Claire M Vajdic, Eric A Engels, Lindsay M Morton, Paige M Bracci, John J Spinelli, Tongzhang Zheng, Yawei Zhang, Silvia Franceschi and 15 more

Abstract readMeta-AnalysisMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

139 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Human Pegivirus Infection and Lymphoma Risk: A Systematic Review and Meta-analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
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  9. Increased risk for lymphoid and myeloid neoplasms in elderly solid-organ transplant recipients.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2010
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79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Silvia de SanjoseUnit of Infections and Cancer, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge, Centro de Investigación Biomédica en Red Epidemiología y Salud Pública, Barcelona, Spain. s.sanjose@iconcologia.net
Yolanda Benavente
Claire M Vajdic
Eric A Engels
Lindsay M Morton
Paige M Bracci
John J Spinelli
Tongzhang Zheng
Yawei Zhang
Silvia Franceschi
Renato Talamini
Elizabeth A Holly
Andrew E Grulich
James R Cerhan
Patricia Hartge
Wendy Cozen
Paolo Boffetta
Paul Brennan
Marc Maynadié
Pierluigi Cocco
Ramon Bosch
Lenka Foretova
Anthony Staines
Nikolaus Becker
Alexandra Nieters

Funding

Epidemiology /Natural History--Cancer-Associated VirusesZ01CP010176 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MBULAITEYE, SAM M · 2001 to 2008
$11.3M
Multidisciplinary Studies of LymphomaZIACP010170 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MORTON, LINDSAY · 2009 to 2025
$10.7M
Molecular Epidemiology of non Hodgkin's LymphomaR01CA087014 · NCI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI HOLLY, ELIZABETH A. · 2001 to 2005
$6.7M
SURVEILLANCE, EPIDEMIOLOGY, AND END RESULTS--SEERN01PC065064 · PC · WAYNE STATE UNIVERSITY · PI WEISS, LINDA K · 1996 to 2000
$4.5M
EPIDEMIOLOGY OF NON HODGKINS'S LYMPHOMA DATA ANALYSISR03CA089745 · NCI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI HOLLY, ELIZABETH A. · 2001 to 2002
$148k
HAIR DYE USE AND RISK OF NONHODGKINS LYMPHOMAR01CA062006 · NCI · YALE UNIVERSITY · PI ZHENG, TONGZHANG · 1995 to 2000
$125k
HEMATOLYMPHOPOIETIC MALIGNANCIES IN ITALYR01CA051086 · NCI · UNIVERSITA DI TORINO · PI VINEIS, PAOLO · 1991 to 1993
–
Intramural NIH HHS ZIA CP010170NCI NIH HHS CA104682NCI NIH HHS CA51086NCI NIH HHS CA62006NCI NIH HHS CA87014NCI NIH HHS CA89745NCI NIH HHS PC65064NCI NIH HHS PC67008NCI NIH HHS PC67009NCI NIH HHS PC67010NCI NIH HHS PC71105PHS HHS A45614
6 · The paper itself

Abstract

BACKGROUND &

aimsIncreasing evidence points towards a role of hepatitis C virus (HCV) infection in causing malignant lymphomas. We pooled case-control study data to provide robust estimates of the risk of non-Hodgkin's lymphoma (NHL) subtypes after HCV infection.

methodsThe analysis included 7 member studies from the International Lymphoma Epidemiology Consortium (InterLymph) based in Europe, North America, and Australia. Adult cases of NHL (n = 4784) were diagnosed between 1988 and 2004 and controls (n = 6269) were matched by age, sex, and study center. All studies used third-generation enzyme-linked immunosorbent assays to test for antibodies against HCV in serum samples. Participants who were human immunodeficiency virus positive or were organ-transplant recipients were excluded.

resultsHCV infection was detected in 172 NHL cases (3.60%) and in 169 (2.70%) controls (odds ratio [OR], 1.78; 95% confidence interval [CI], 1.40-2.25). In subtype-specific analyses, HCV prevalence was associated with marginal zone lymphoma (OR, 2.47; 95% CI, 1.44-4.23), diffuse large B-cell lymphoma (OR, 2.24; 95% CI, 1.68-2.99), and lymphoplasmacytic lymphoma (OR, 2.57; 95% CI, 1.14-5.79). Notably, risk estimates were not increased for follicular lymphoma (OR, 1.02; 95% CI, 0.65-1.60).

conclusionsThese results confirm the association between HCV infection and NHL and specific B-NHL subtypes (diffuse large B-cell lymphoma, marginal zone lymphoma, and lymphoplasmacytic lymphoma).

Indexed as

AdolescentAdultAgedAged, 80 and overAustraliaCase-Control StudiesEnzyme-Linked Immunosorbent AssayEuropeFemaleHepatitis CHumansLogistic ModelsLymphoma, B-CellMaleMiddle AgedPrevalence

Identifiers

PMID18387498
PMCPMC3962672

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.