ArticleBiochemical and biophysical research communications2008
Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts.
Article in Biochemical and biophysical research communications, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 72 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
72 citing papers in PubMed, 152 citations in OpenAlex.
- MicroRNAs as novel biomarkers for the diagnosis and treatment of pediatric diseases.Clinical and experimental pediatrics · 2024Article
- Serum microRNAs associated with concussion in football players.Frontiers in neurology · 2023Article
- Insights into role of microRNAs in cardiac development, cardiac diseases, and developing novel therapies.Iranian journal of basic medical sciences · 2020Review
- MicroRNA Expression Profile in the Prenatal Amniotic Fluid Samples of Pregnant Women with Down Syndrome.Balkan medical journal · 2018Article
- Increased miR-223 expression in foetal organs is a signature of acute chorioamnionitis with systemic consequences.Journal of cellular and molecular medicine · 2018Article
- Prognostic Value of MicroRNAs in Preoperative Treated Rectal Cancer.International journal of molecular sciences · 2016Article
- Investigation of Gene Regulatory Networks Associated with Autism Spectrum Disorder Based on MiRNA Expression in China.PloS one · 2015Article
- miR-99a directly targets the mTOR signalling pathway in breast cancer side population cells.Cell proliferation · 2014Article
- miR-10a and miR-10b target the 3'-untranslated region of TBX5 to repress its expression.Pediatric cardiology · 2014Article
- Article
- microRNAs as potential regulators of myeloid-derived suppressor cell expansion.Innate immunity · 2014Review
- Integrated analysis of microRNAs and their disease related targets in the brain of mice infected with West Nile virus.Virology · 2014Article
- Differentially expressed microRNAs in maternal plasma for the noninvasive prenatal diagnosis of Down syndrome (trisomy 21).BioMed research international · 2014Article
- Identification and profiling of microRNAs in the embryonic breast muscle of pekin duck.PloS one · 2014Article
- Extracellular chromosome 21-derived microRNAs in euploid & aneuploid pregnancies.The Indian journal of medical research · 2013Article
- Exploration of miRNA families for hypotheses generation.Scientific reports · 2013Article
- MicroRNAs: a new piece in the paediatric cardiovascular disease puzzle.Cardiology in the young · 2013Review
- Review
- Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.Nature medicine · 2013Article
- MicroRNAs and intellectual disability (ID) in Down syndrome, X-linked ID, and Fragile X syndrome.Frontiers in cellular neuroscience · 2013Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2013-07-05Falsification/Fabrication of Data · Investigation by Company/Institution · Investigation by ORI · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · · NIH Finding of misconduct against Terry S Elton
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- Retracted
Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
Down syndrome (DS), or Trisomy 21, is the most common genetic cause of cognitive impairment and congenital heart defects in the human population. To date, the contribution of microRNAs (miRNAs) in DS has not been investigated. Bioinformatic analyses demonstrate that human chromosome 21 (Hsa21) harbors five miRNA genes; miR-99a, let-7c, miR-125b-2, miR-155, and miR-802. MiRNA expression profiling, miRNA RT-PCR, and miRNA in situ hybridization experiments demonstrate that these miRNAs are overexpressed in fetal brain and heart specimens from individuals with DS when compared with age- and sex-matched controls. We hypothesize that trisomic 21 gene dosage overexpression of Hsa21-derived miRNAs results in the decreased expression of specific target proteins and contribute, in part, to features of the neuronal and cardiac DS phenotype. Importantly, Hsa21-derived miRNAs may provide novel therapeutic targets in the treatment of individuals with DS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.