ArticleMicrocirculation (New York, N.Y. : 1994)2008
Effects of old age on vascular complexity and dispersion of the hepatic sinusoidal network.
Article in Microcirculation (New York, N.Y. : 1994), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- The Anatomical Landscape of Living Donor Livers: A 101-Case Retrospective Single-Center Study in Indonesia From 2010 to 2025.Annals of transplantation · 2026Article
- Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy.Redox report : communications in free radical research · 2024Review
- Fractal nature of human gastrointestinal system: Exploring a new era.World journal of gastroenterology · 2023Review
- Innate immune surveillance of the circulation: A review on the removal of circulating virions from the bloodstream.PLoS pathogens · 2022Review
- Dysregulated Neurovascular Control Underlies Declining Microvascular Functionality in People With Non-alcoholic Fatty Liver Disease (NAFLD) at Risk of Liver Fibrosis.Frontiers in physiology · 2020Article
- Biofabrication strategies for creating microvascular complexity.Biofabrication · 2019Review
- Primary rat LSECs preserve their characteristic phenotype after cryopreservation.Scientific reports · 2018Article
- Analyzing the human liver vascular architecture by combining vascular corrosion casting and micro-CT scanning: a feasibility study.Journal of anatomy · 2014Article
- Mast cells and the liver aging process.Immunity & ageing : I & A · 2013Article
- Fractal structure of the liver: effect on drug elimination.Journal of pharmacokinetics and pharmacodynamics · 2013Article
- A Sieve-Raft Hypothesis for the regulation of endothelial fenestrations.Computational and structural biotechnology journal · 2013Review
- The influence of old age and poloxamer-407 on the hepatic disposition of diazepam in the isolated perfused rat liver.Pharmacology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 4 countries.
Funding
Abstract
objectivesIn old age, there are marked changes in both the structure of the liver sinusoidal endothelial cell and liver perfusion. The objective of this study was to determine whether there are also aging changes in the microvascular architecture and vascular dispersion of the liver that might influence liver function.
methodsVascular corrosion casts and light micrographs of young (4 months) and old (24 months) rat livers were compared. Fractal and Fourier analyses and micro-computed tomography were used. Vascular dispersion was determined from the dispersion number for sucrose and 100-nm microspheres in impulse response experiments.
resultsAge did not affect sinusoidal dimensions, sinusoidal density, or dispersion number. There were changes in the geometry and complexity of the sinusoidal network as determined by fractal dimension and degree of anisotropy.
conclusionsThere are small, age-related changes in the architecture of the liver sinusoidal network, which may influence hepatic function and reflect broader aging changes in the microcirculation. However, sinusoidal dimensions and hepatic vascular dispersion are not markedly influenced by old age.
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