Evidence map›Paper›PMID 18386093›Full record

ReviewLasers in medical science2009

Evaluation of collagen in atherosclerotic plaques: the use of two coherent laser-based imaging methods.

Seemantini K Nadkarni, Brett E Bouma, Johannes de Boer, Guillermo J Tearney

Abstract readEvaluation StudyReview
In one paragraph

Review in Lasers in medical science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Extreme Diversity of the Human Vascular Mesenchymal Cell Landscape.Journal of the American Heart Association · 2020
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Seemantini K NadkarniHarvard Medical School, Massachusetts General Hospital and Wellman Center for Photomedicine, Boston, MA 02114, USA. snadkarni@hms.harvard.edu
Brett E Bouma
Johannes de Boer
Guillermo J Tearney

Funding

Natural History of Vulnerable Coronary PlaquesR01HL076398 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BOUMA, BRETT E, TEARNEY, GUILLERMO J · 2004 to 2015
$7.5M
NHLBI NIH HHS R01 HL076398
6 · The paper itself

Abstract

Acute coronary events such as myocardial infarction are frequently caused by the rupture of unstable atherosclerotic plaque. Collagen plays a key role in determining plaque stability. Methods to measure plaque collagen content are invaluable in detecting unstable atherosclerotic plaques. Recently, novel coherent laser-based imaging techniques, such as polarization-sensitive optical coherence tomography (PSOCT) and laser speckle imaging (LSI) have been investigated, and they provide a wealth of information related to collagen content and plaque stability. Additionally, given their potential for intravascular use, these technologies will be invaluable for improving our understanding of the natural history of plaque development and rupture and, hence, enable the detection of unstable plaques. In this article we review recent developments in these techniques and potential challenges in translating these methods into intra-arterial use in patients.

Indexed as

LasersAtherosclerosisCollagenCoronary Artery DiseaseHumansMuscle, Smooth, VascularTomography, Optical CoherenceCollagen

Identifiers

PMID18386093
PMCPMC2776077

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.