ArticleLasers in medical science2009
Red light of 647 nm enhances osteogenic differentiation in mesenchymal stem cells.
Article in Lasers in medical science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of low-level laser therapy on mesenchymal stem cell proliferation: a systematic review.Lasers in medical science · 2015Pooled it
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- Boosting osteoblast differentiation: enhancing the effects of low-level blue laser therapy on human embryonic stem cell-derived mesenchymal stem cells to improve viability and calcium deposition.Lasers in medical science · 2025Article
- Influence of Low-Level Red Laser Irradiation on the Proliferation, Viability, and Differentiation of Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells.Life (Basel, Switzerland) · 2025Article
- Effect of magnesium oxide nanoparticles and LED irradiation on the viability and differentiation of human stem cells of the apical papilla.Biotechnology letters · 2024Article
- Red light-emitting diode therapy minimizes the functional deleterious effects of the antiretroviral ritonavir on osteoblasts in vitro.Lasers in medical science · 2024Article
- Enhancing osteogenic differentiation in adipose-derived mesenchymal stem cells with Near Infra-Red and Green Photobiomodulation.Regenerative therapy · 2023Article
- Photobiomodulation therapy upregulates the growth kinetics and multilineage differentiation potential of human dental pulp stem cells-an in vitro Study.Lasers in medical science · 2022Article
- Control of stem cell differentiation by using extrinsic photobiomodulation in conjunction with cell adhesion pattern.Scientific reports · 2022Article
- The Effect of Beam Direction on Absorption and Transmission of Ultraviolet to Infrared Wavelength Regions in Three Different Dentin Thicknesses.Journal of lasers in medical sciences · 2022Article
- Irradiation with red light-emitting diode enhances proliferation and osteogenic differentiation of periodontal ligament stem cells.Lasers in medical science · 2021Article
- The Effect of Photobiomodulation on Human Mesenchymal Cells: A Literature Review.Aesthetic plastic surgery · 2021Review
- Irradiation by high-intensity red light-emitting diode enhances human bone marrow mesenchymal stem cells osteogenic differentiation and mineralization through Wnt/β-catenin signaling pathway.Lasers in medical science · 2021Article
- Photobiomodulation: An Effective Approach to Enhance Proliferation and Differentiation of Adipose-Derived Stem Cells into Osteoblasts.Stem cells international · 2021Review
- Laser Photobiomodulation 808 nm: Effects on Gene Expression in Inflammatory and Osteogenic Biomarkers in Human Dental Pulp Stem Cells.Frontiers in pharmacology · 2021Article
- Effects of 405-, 532-, 650-, and 940-nm wavelengths of low-level laser therapies on orthodontic tooth movement in rats.Progress in orthodontics · 2020Article
- Can Low-Level Laser and Light-Emitting Diode Enhance the Stability of Dental Implants?Journal of maxillofacial and oral surgery · 2020Article
- Photobiomodulation effects on osteogenic differentiation of adipose-derived stem cells.Cytotechnology · 2020Article
- The Effects of Photobiomodulation on MC3T3-E1 Cells via 630 nm and 810 nm Light-Emitting Diode.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Photostimulation of osteogenic differentiation on silk scaffolds by plasma arc light source.Lasers in medical science · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of light for medical treatment has been studied previously. In this study, we examined the effect of light from a red light-emitting diode on osteogenic differentiation of mouse mesenchymal stem cells (D1 cells) which were cultured in the presence of osteogenic differentiation medium (ODM) for 3 days, then exposed to a red light-emitting diode (LED) light of 647 nm wavelength once for 10 s, 30 s or 90 s with radiation energies of 0.093 J, 0.279 J and 0.836 J, respectively. D1 cells in the presence of ODM differentiated into osteoblasts, and this process was enhanced on exposure to LED light in ODM medium. This effect was confirmed by increased Alizarin red staining, higher alkaline phosphatase (ALP) activity, higher mRNA expressions of osteocalcin, collagen type I, osteopontin and Runt-related transcription factor2 (Runx2), and higher levels by reverse transcriptase-polymerase chain reaction (RT-PCR) and by increased immunofluorescence staining against cluster of differentiation 44 (CD44) by immunofluorescence microscopy, confocal microscopy and flow cytometric analysis. These data suggest that osteogenic differentiation of mesenchymal stem cells (MSCs) in ODM is enhanced by LED light exposure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.