ArticleVirchows Archiv : an international journal of pathology2008
Trisomy of chromosome 6 in Merkel cell carcinoma within lymph nodes.
Article in Virchows Archiv : an international journal of pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Imaging Specific Genomic DNA in Living Cells.Annual review of biophysics · 2016Review
- Mutational analysis of merkel cell carcinoma.Cancers · 2014Review
- Working formulation of neuroendocrine tumors of the skin and breast.Endocrine pathology · 2014Review
- Pituitary metastasis of Merkel cell carcinoma.Journal of neuro-oncology · 2010Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
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Abstract
Merkel cell carcinoma (MCC) of the skin is a neuroendocrine tumor with characteristic histological and immunohistochemical features. Among various cytogenetic changes, trisomy of chromosome 6 has been reported in 47% of cases using in situ hybridization. Primary tumors, morphologically and immunohistochemically identical to MCCs of the skin, have been described in other organs, including lymph nodes. Here, a cytogenetic study of four cases of MCC of lymph nodes is presented. Four cases of primary MCCs of lymph nodes and ten cases of cutaneous MCCs were studied for chromosome 6 using fluorescent in situ hybridization (FISH). All cases showed typical features of MCC both at hematoxylin and eosin (H&E) and immunohistochemistry. FISH showed trisomy 6 in two out of the four cases ofMCCs of lymph node as well as in 6 out 10 cases of MCCs of skin. Lymph nodal and cutaneous MCCs share same histological and immunohistochemical features, as well as same cytogenetic alteration for chromosome 6. It seems that there are more similarities than differences between cutaneous and lymph nodal MCCs. Whether lymph nodal MCCs are primary tumors or metastases from regressed skin lesions is still questionable, although several findings indicate a primary origin.
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