Evidence map›Paper›PMID 18385988›Full record

ArticleExperimental brain research2008

High- and low-frequency repetitive transcranial magnetic stimulation differentially activates c-Fos and zif268 protein expression in the rat brain.

Selcen Aydin-Abidin, Jörn Trippe, Klaus Funke, Ulf T Eysel, Alia Benali

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Article in Experimental brain research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 4 pooled it
7.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 4 syntheses or guidelines pooled it, 162 citations in OpenAlex.

  1. Pooled it
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  7. Magnetic stimulation of carotid sinus as a treatment for hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2019
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  13. Differential neural responses to rhythmic and patterned TMS protocols: Insights from EEG spectral analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  20. Engram mechanisms of memory linking and identity.Nature reviews. Neuroscience · 2024
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Selcen Aydin-AbidinDepartment of Neurophysiology, Medical Faculty, Ruhr-University Bochum, 44780, Bochum, Germany.
Jörn Trippe
Klaus Funke
Ulf T Eysel
Alia Benali
Ruhr University Bochum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repetitive transcranial magnetic stimulation (rTMS) has been shown to alter cortical excitability depending on the stimulus-frequency used, with high frequency (5 Hz and higher) increasing it but low frequency (usually 1 Hz or lower) reducing it. To determine the efficiency of different rTMS protocols in inducing cortical network activity, we tested the acute effect of one low-frequency rTMS protocol (1 Hz) and two different high-frequency protocols (10 Hz and intermittent theta-burst stimulation, iTBS) on the expression of the two immediate early gene (IEG) proteins c-Fos and zif268 in the rat brain. The cortical expression of both IEGs was specifically changed in an rTMS-dependent manner. One and 10 Hz rTMS enhanced c-Fos protein expression in all cortical areas tested, while iTBS was effective only in limbic cortices. Zif268 expression was increased in almost all cortical areas after iTBS, while 10 Hz rTMS was effective only in the primary motor and sensory cortices. One Hertz rTMS had no effect on cortical zif268 expression. Furthermore, sham-rTMS had no effect on zif268 expression but increased c-Fos in limbic cortices. This is the first study demonstrating that cortical zif268 and c-Fos expression can be specifically modulated by acute rTMS depending on the pattern of stimulation applied.

Indexed as

Electromagnetic FieldsAnimalsBrainBrain MappingCell CountCerebral CortexEarly Growth Response Protein 1Evoked PotentialsGene Expression RegulationGenes, Immediate-EarlyImmunohistochemistryLimbic SystemMaleNerve NetProto-Oncogene Proteins c-fosRatsEarly Growth Response Protein 1Egr1 protein, ratProto-Oncogene Proteins c-fos

Identifiers

PMID18385988
OpenAlexW2044655131

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.