Evidence map›Paper›PMID 18385838›Full record

ArticleOrganic & biomolecular chemistry2008

A highly fluorescent nucleoside analog based on thieno[3,4-d]pyrimidine senses mismatched pairing.

Seergazhi G Srivatsan, Haim Weizman, Yitzhak Tor

Abstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Total RNA Synthesis and its Covalent Labeling Innovation.Topics in current chemistry (Cham) · 2022
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Emissive RNA alphabet.Journal of the American Chemical Society · 2011
    Article
  11. Multisensing emissive pyrimidine.Chemphyschem : a European journal of chemical physics and physical chemistry · 2011
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. FRET enabled real time detection of RNA-small molecule binding.Journal of the American Chemical Society · 2009
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Seergazhi G SrivatsanDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0358, USA.
Haim Weizman
Yitzhak Tor

Funding

Fluorescent Nucleosides and OligonucleotidesR01GM069773 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TOR, YITZHAK · 2004 to 2020
$5.0M
NIGMS NIH HHS GM 069773NIGMS NIH HHS R01 GM069773
6 · The paper itself

Abstract

A highly emissive nucleobase analog, based on a thieno[3,4-d]pyrimidine core, is enzymatically incorporated into RNA oilgonucleotides that function as base discriminating fluorescent probes.

Indexed as

Base Pair MismatchDNAFluorescent DyesMolecular StructureNucleosidesOligonucleotidesRNASensitivity and SpecificityTime Factors7-ribofuranosylthieno(3,4-d)pyrimidine-3,6-dioneDNAFluorescent DyesNucleosidesOligonucleotidesRNA

Identifiers

PMID18385838
PMCPMC5263222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.