ArticleJournal of clinical biochemistry and nutrition2008
Application of heme oxygenase-1, carbon monoxide and biliverdin for the prevention of intestinal ischemia/reperfusion injury.
Article in Journal of clinical biochemistry and nutrition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 92 citations in OpenAlex.
- Comprehensive analysis of genes associated with necroptosis and pyroptosis in intestinal ischemia-reperfusion injury.PloS one · 2025Article
- Effects of Mesobiliverdin IXα-Enriched Microalgae Feed on Gut Health and Microbiota of Broilers.Frontiers in veterinary science · 2020Article
- Biliverdin administration regulates the microRNA-mRNA expressional network associated with neuroprotection in cerebral ischemia reperfusion injury in rats.International journal of molecular medicine · 2019Article
- Preparation of a Nile Red-Pd-based fluorescent CO probe and its imaging applications in vitro and in vivo.Nature protocols · 2018Article
- Photoactivated in Vitro Anticancer Activity of Rhenium(I) Tricarbonyl Complexes Bearing Water-Soluble Phosphines.Inorganic chemistry · 2018Article
- Transduced PEP-1-Heme Oxygenase-1 Fusion Protein Attenuates Lung Injury in Septic Shock Rats.Oxidative medicine and cellular longevity · 2018Article
- Article
- Carbon monoxide and the CNS: challenges and achievements.British journal of pharmacology · 2015Review
- Protective role of hemeoxygenase-1 in gastrointestinal diseases.Cellular and molecular life sciences : CMLS · 2015Review
- Kaempferol pretreatment modulates systemic inflammation and oxidative stress following hemorrhagic shock in mice.Chinese medicine · 2015Article
- Propofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation model.Oxidative medicine and cellular longevity · 2014Article
- Heme oxygenase-1 and gut ischemia/reperfusion injury: A short review.World journal of gastroenterology · 2013Review
- Heme oxygenase-1 deficiency promotes the development of necrotizing enterocolitis-like intestinal injury in a newborn mouse model.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Ginsenoside Rb1 attenuates intestinal ischemia reperfusion induced renal injury by activating Nrf2/ARE pathway.Molecules (Basel, Switzerland) · 2012Article
- A hypothesis on biological protection from space radiation through the use of new therapeutic gases as medical counter measures.Medical gas research · 2012Article
- Ischemic preconditioning and remote ischemic preconditioning have protective effect against cold ischemia-reperfusion injury of rat small intestine.Pediatric surgery international · 2011Article
- Carbon monoxide liberated from carbon monoxide-releasing molecule exerts an anti-inflammatory effect on dextran sulfate sodium-induced colitis in mice.Digestive diseases and sciences · 2011Article
- Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences.Langenbeck's archives of surgery · 2011Review
- Heme oxygenase in the regulation of vascular biology: from molecular mechanisms to therapeutic opportunities.Antioxidants & redox signaling · 2011Review
- Inhalation of carbon monoxide ameliorates TNBS-induced colitis in mice through the inhibition of TNF-α expression.Digestive diseases and sciences · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intestinal ischemia/reperfusion (I/R) injury occurs frequently in a variety of clinical settings, including mesenteric artery occlusion, abdominal aneurism surgery, trauma, shock, and small intestinal transplantation, and is associated with substantial morbidity and mortality. Although the exact mechanisms involved in the pathogenesis of intestinal I/R injury have not been fully elucidated, it is generally believed that polymorphonuclear neutrophils, pro-inflammatory cytokines, and mediators generated in the setting of oxidative stress, such as reactive oxygen species (ROS), play important roles. Heme oxygenase (HO) is the rate-limiting enzyme that catalyzes the degradation of heme into equimolar quantities of biliverdin and carbon monoxide (CO), while the central iron is released. An inducible form of HO (HO-1), biliverdin, and CO, have been shown to possess generalized endogenous anti-inflammatory activities and provide protection against intestinal I/R injury. Further, recent observations have demonstrated that exogenous HO-1 expression, as well as exogenously administered CO and biliverdin, have potent cytoprotective effects on intestinal I/R injury as well. Here, we summarize the currently available data regarding the role of the HO system in the prevention intestinal I/R injury.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.