ArticleJournal of clinical biochemistry and nutrition2008
Proton pump inhibitors and gastritis.
Article in Journal of clinical biochemistry and nutrition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Long-term proton pump inhibitor (PPI) use and the development of gastric pre-malignant lesions.The Cochrane database of systematic reviews · 2014Pooled it
- A biochemical study on the gastroprotective effect of andrographolide in rats induced with gastric ulcer.Indian journal of pharmaceutical sciences · 2011Article
- Epidemiological aspects of gastric adenocarcinoma: are predictive diagnostics and targeted preventive measures possible?The EPMA journal · 2010Article
- Progression from chronic atrophic gastritis to gastric cancer; tangle, toggle, tackle with Korea red ginseng.Journal of clinical biochemistry and nutrition · 2010Article
- Bile acids induce cdx2 expression through the farnesoid x receptor in gastric epithelial cells.Journal of clinical biochemistry and nutrition · 2010Article
- The expression of heme oxygenase-1 induced by lansoprazole.Journal of clinical biochemistry and nutrition · 2009Article
- Lansoprazole, a Proton Pump Inhibitor, Suppresses Production of Tumor Necrosis Factor-alpha and Interleukin-1beta Induced by Lipopolysaccharide and Helicobacter Pylori Bacterial Components in Human Monocytic Cells via Inhibition of Activation of Nuclear Factor-kappaB and Extracellular Signal-Regulated Kinase.Journal of clinical biochemistry and nutrition · 2009Article
- pH regulators to target the tumor immune microenvironment in human hepatocellular carcinoma.OncoimmunologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proton pump inhibitors (PPIs) are novel compounds that strongly inhibit the H(+)/K(+)-ATPase in the gastric parietal cells to cause profound suppression of acid secretion. Acid-generating ATPase, also known as vacuolar-type ATPase, is located in the lysozomes of leukocytes and osteoclasts and its activity is also reportedly influenced by treatment with PPIs. This concept is supported by the results of studies using autoradiography in which (3)H-Lansoprazole uptake sites were clearly detected in the cytoplasmic granules of neutrophils infiltrating the gastric mucosa. In vitro studies indicate that PPIs increase the intra-vacuolar pH in the lysosomes of purified neutrophils and attenuate the adherence of neutrophils to the vascular endothelium. In clinical practice, the acidic environment in the stomach plays a critical role in the development of gastritis induced by Helicobacter pylori (H. pylori). This is worthy of note, because persistent gastritis often results in atrophic and metaplastic changes in the gastric mucosa, which are believed to be preneoplastic abnormalities. In patients with H. pylori-infection, PPI therapy causes corpus-predominant gastritis, which is frequently found in the background mucosa in patients with gastric cancer. The efficacy and safety of long-term PPI-treatment have not been conclusive, thus we need to pay more attention to the additional pharmacological actions of PPIs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.