ArticleThe Journal of investigative dermatology2008
Activation of keratinocyte protein kinase C zeta in psoriasis plaques.
Article in The Journal of investigative dermatology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Features of the CD1 gene family in rodents and the uniqueness of the immune system of naked mole-rat.Biology direct · 2024Article
- Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases.Frontiers in immunology · 2022Review
- Dysregulated Peripheral Invariant Natural Killer T Cells in Plaque Psoriasis Patients.Frontiers in cell and developmental biology · 2021Article
- Effects of moving cupping therapy for plaque psoriasis: study protocol for a randomized multicenter clinical trial.Trials · 2020Article
- Linking CD1-Restricted T Cells With Autoimmunity and Dyslipidemia: Lipid Levels Matter.Frontiers in immunology · 2018Review
- PKCζ as a promising therapeutic target for TNFα-induced inflammatory disorders in chronic cutaneous wounds.International journal of molecular medicine · 2017Article
- Inflammation dependent mTORC1 signaling interferes with the switch from keratinocyte proliferation to differentiation.PloS one · 2017Article
- Dysregulated expression of inflammation-related genes in psoriatic dermis mesenchymal stem cells.Acta biochimica et biophysica Sinica · 2016Article
- Characterization of the interaction of staphylococcal enterotoxin B with CD1d expressed in human renal proximal tubule epithelial cells.BMC microbiology · 2015Article
- Therapeutic manipulation of natural killer (NK) T cells in autoimmunity: are we close to reality?Clinical and experimental immunology · 2013Review
- Contact-dependent interference with invariant NKT cell activation by herpes simplex virus-infected cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice.The Journal of clinical investigation · 2011Article
- Imiquimod-induced TLR7 signaling enhances repair of DNA damage induced by ultraviolet light in bone marrow-derived cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Th17/Tc17 infiltration and associated cytokine gene expression in elicitation phase of allergic contact dermatitis.The British journal of dermatology · 2009Article
- Protein microarrays identify antibodies to protein kinase Czeta that are associated with a greater risk of allograft loss in pediatric renal transplant recipients.Kidney international · 2009Article
- A central role for transcription factor C/EBP-beta in regulating CD1d gene expression in human keratinocytes.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
PKCzeta (protein kinase C-zeta), a member of protein kinase C family, plays an important role in cell proliferation, differentiation, and apoptosis. It acts as a downstream molecule for TNF-alpha (tumor necrosis factor) signal transduction and also regulates the expression of CD1d, an HLA-class I-like molecule. The interaction of CD1d with natural killer T (NKT) cells has been shown to be important in their Th1 cytokine production in psoriasis. In this study, we examined PKCzeta in psoriasis in order to define its role in the pathogenesis of the disease. We found that T-cell receptor (TCR) V alpha24+ V beta11+ NKT cells and CD1d molecules within psoriatic skin were increased. Moreover, there was an associated increase in PKCzeta mRNA and protein expression with membrane translocation in psoriasis lesions compared to uninvolved skin. Furthermore, cultured keratinocytes exhibited increased PKCzeta activity and membrane translocation upon stimulation by TNF-alpha, a cytokine known to play an important role in the pathogenesis of psoriasis. These results implied that PKCzeta is an important transduction molecule downstream of TNF-alpha signaling and is associated with increased expression of CD1d that may enhance CD1d-NKT cell interactions in psoriasis lesions. This makes PKCzeta a tempting target for possible pharmacological intervention in modifying the downstream effects of TNF-alpha in psoriasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.