ArticleMolecular biology of the cell2008
RAB-11 permissively regulates spindle alignment by modulating metaphase microtubule dynamics in Caenorhabditis elegans early embryos.
Article in Molecular biology of the cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- An RNAi screen of Rab GTPase genes in Caenorhabditis elegans reveals that morphogenesis has a higher demand than stem cell niche maintenance for rab-1 in the somatic cells of the reproductive system.G3 (Bethesda, Md.) · 2025Article
- Optimized PAR-2 RING dimerization mediates cooperative and selective membrane binding for robust cell polarity.The EMBO journal · 2024Article
- Article
- RAB11A and RAB11B control mitotic spindle function in intestinal epithelial progenitor cells.EMBO reports · 2023Article
- Rabs in Signaling and Embryonic Development.International journal of molecular sciences · 2020Review
- Loss of MYO5B expression deregulates late endosome size which hinders mitotic spindle orientation.PLoS biology · 2019Article
- Physical Limits on the Precision of Mitotic Spindle Positioning by Microtubule Pushing forces: Mechanics of mitotic spindle positioning.BioEssays : news and reviews in molecular, cellular and developmental biology · 2017Review
- Small RAB GTPases Regulate Multiple Steps of Mitosis.Frontiers in cell and developmental biology · 2016Review
- Spindlegate: the biological consequences of disrupting traffic.Developmental cell · 2014Article
- Rab11 endosomes contribute to mitotic spindle organization and orientation.Developmental cell · 2014Article
- A new role for Rab GTPases during early mitotic stages.Small GTPases · 2014Article
- Cancer driver candidate genes AVL9, DENND5A and NUPL1 contribute to MDCK cystogenesis.Oncoscience · 2014Article
- Article
- RAB-5 controls the cortical organization and dynamics of PAR proteins to maintain C. elegans early embryonic polarity.PloS one · 2012Article
- Long astral microtubules and RACK-1 stabilize polarity domains during maintenance phase in Caenorhabditis elegans embryos.PloS one · 2011Article
- Opening ahead: early steps in lumen formation revealed.Nature cell biology · 2010Article
- A molecular network for de novo generation of the apical surface and lumen.Nature cell biology · 2010Article
- Polarity and endocytosis: reciprocal regulation.Trends in cell biology · 2010Review
- A role for separase in the regulation of RAB-11-positive vesicles at the cleavage furrow and midbody.Current biology : CB · 2010Article
- Dual roles for the Drosophila PI 4-kinase four wheel drive in localizing Rab11 during cytokinesis.The Journal of cell biology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Alignment of the mitotic spindle along a preformed axis of polarity is crucial for generating cell diversity in many organisms, yet little is known about the role of the endomembrane system in this process. RAB-11 is a small GTPase enriched in recycling endosomes. When we depleted RAB-11 by RNAi in Caenorhabditis elegans, the spindle of the one-cell embryo failed to align along the axis of polarity in metaphase and underwent violent movements in anaphase. The distance between astral microtubules ends and the anterior cortex was significantly increased in rab-11(RNAi) embryos specifically during metaphase, possibly accounting for the observed spindle alignment defects. Additionally, we found that normal ER morphology requires functional RAB-11, particularly during metaphase. We hypothesize that RAB-11, in conjunction with the ER, acts to regulate cell cycle-specific changes in astral microtubule length to ensure proper spindle alignment in Caenorhabditis elegans early embryos.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.