ArticleJournal of neurophysiology2008
Spike-firing resonance in hypoglossal motoneurons.
Article in Journal of neurophysiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- The voltage and spiking responses of subthreshold resonant neurons to structured and fluctuating inputs: persistence and loss of resonance and variability.Biological cybernetics · 2022Review
- Mechanisms Contributing to the Generation of Mayer Waves.Frontiers in neuroscience · 2020Article
- Frequency-dependent responses of neuronal models to oscillatory inputs in current versus voltage clamp.Biological cybernetics · 2019Article
- Active membrane conductances and morphology of a collision detection neuron broaden its impedance profile and improve discrimination of input synchrony.Journal of neurophysiology · 2019Article
- Membrane potential resonance in non-oscillatory neurons interacts with synaptic connectivity to produce network oscillations.Journal of computational neuroscience · 2019Article
- M current regulates firing mode and spike reliability in a collision-detecting neuron.Journal of neurophysiology · 2018Article
- Spiking resonances in models with the same slow resonant and fast amplifying currents but different subthreshold dynamic properties.Journal of computational neuroscience · 2017Article
- Coding Properties of Three Intrinsically Distinct Retinal Ganglion Cells under Periodic Stimuli: A Computational Study.Frontiers in computational neuroscience · 2016Article
- Influence of developmental nicotine exposure on spike-timing precision and reliability in hypoglossal motoneurons.Journal of neurophysiology · 2015Article
- A computational study of spike time reliability in two types of threshold dynamics.Journal of mathematical neuroscience · 2013Article
- Fast oscillations during gasping and other non-eupneic respiratory behaviors: Clues to central pattern generation.Respiratory physiology & neurobiology · 2013Review
- Motoneuron firing patterns underlying fast oscillations in phrenic nerve discharge in the rat.Journal of neurophysiology · 2012Article
- Cortical entrainment of human hypoglossal motor unit activities.Journal of neurophysiology · 2012Article
- Synchronization of presynaptic input to motor units of tongue, inspiratory intercostal, and diaphragm muscles.Journal of neurophysiology · 2011Article
- GAD67-GFP+ neurons in the Nucleus of Roller: a possible source of inhibitory input to hypoglossal motoneurons. I. Morphology and firing properties.Journal of neurophysiology · 2011Article
- GAD67-GFP+ neurons in the Nucleus of Roller. II. Subthreshold and firing resonance properties.Journal of neurophysiology · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
During an inspiration the output of hypoglossal (XII) motoneurons (HMs) in vitro is characterized by synchronous oscillatory firing in the 20- to 40-Hz range. To maintain synchronicity it is important that the cells fire with high reliability and precision. It is not known whether the intrinsic properties of HMs are tuned to maintain synchronicity when stimulated with time-varying inputs. We intracellularly recorded from HMs in an in vitro brain stem slice preparation from juvenile mice. Cells were held at or near spike threshold and were stimulated with steady or swept sine-wave current functions (10-s duration; 0- to 40-Hz range). Peristimulus time histograms were constructed from spike times based on threshold crossings. Synaptic transmission was suppressed by including blockers of GABAergic, glycinergic, and glutamatergic neurotransmission in the bath solution. Cells responded to sine-wave stimulation with bursts of action potentials at low (<3- to 5-Hz) sine-wave frequency, whereas they phase-locked 1:1 to the stimulus at intermediate frequencies (3-25 Hz). Beyond the 1:1 frequency range cells were able to phase-lock to subharmonics (1:2, 1:3, or 1:4) of the input frequency. The 1:1 phase-locking range increased with increasing stimulus amplitude and membrane depolarization. Reliability and spike-timing precision were highest when the cells phase-locked 1:1 to the stimulus. Our findings suggest that the coding of time-varying inspiratory synaptic inputs by individual HMs is most reliable and precise at frequencies that are generally lower than the frequency of the synchronous inspiratory oscillatory activity recorded from the XII nerve.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.