ArticleClinical journal of the American Society of Nephrology : CJASN2008
Variations in the risk for cerebrovascular events after kidney transplant compared with experience on the waiting list and after graft failure.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Management of antithrombotic therapies in kidney transplantation candidates and recipients: an ERBP clinical practice document by the DESCaRTES Working Group of ERA and the EKITA Committee of ESOT.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Guideline
- Stroke after lung transplantation: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Generalizability of kidney transplant data in electronic health records - The Epic Cosmos database vs the Scientific Registry of Transplant Recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025Article
- From Risk Assessment to Management: Cardiovascular Complications in Pre- and Post-Kidney Transplant Recipients: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Cerebral blood flow following successful living kidney transplantation: the VINTAGE study.Clinical kidney journal · 2025Article
- Risks of cardiovascular disease and cerebrovascular disease following kidney transplantation: A nationwide, population-based cohort study.International journal of medical sciences · 2025Article
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- Characteristics of stroke after liver and kidney transplantation.Frontiers in neurology · 2023Article
- Characteristics and Prognosis of Stroke in Living Donor Renal Transplant Recipients.Journal of atherosclerosis and thrombosis · 2022Observational
- The Prevalence of Neurological Complication after Renal Transplantation.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Economic impacts of alternative kidney transplant immunosuppression: A national cohort study.Clinical transplantation · 2020Article
- Evolving spectrum of diabetic nephropathy.World journal of diabetes · 2019Review
- Subarachnoid Hemorrhage in Hospitalized Renal Transplant Recipients with Autosomal Dominant Polycystic Kidney Disease: A Nationwide Analysis.Journal of clinical medicine · 2019Article
- Induction immunosuppression agents as risk factors for incident cardiovascular events and mortality after kidney transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019Article
- Treatment of Central Nervous System Complications of Renal Dialysis and Transplantation.Current treatment options in neurology · 2019Review
- Chronic dialysis in patients with end-stage renal disease: Relevance to kidney xenotransplantation.Xenotransplantation · 2019Review
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- The Risk of Stroke in Kidney Transplant Recipients with End-Stage Kidney Disease.International journal of environmental research and public health · 2019Article
- Investigating the Relationship between Cerebral Blood Flow and Cognitive Function in Hemodialysis Patients.Journal of the American Society of Nephrology : JASN · 2019Observational
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
BACKGROUND AND
objectivesThis study examined the risks, predictors, and mortality implications of cerebrovascular disease events after kidney transplantation in a national cohort. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This analysis used United States Renal Data System registry data to study retrospectively Medicare-insured kidney transplant candidates (n = 51,504), recipients (n = 29,614), and recipients with allograft failure (n = 2954) in 1995 through 2002. New-onset cerebrovascular disease events including ischemic stroke, hemorrhagic stroke, and transient ischemic attacks were ascertained from billing records, and participants were followed until Medicare-end or December 31, 2002. Multivariable survival analysis was used to compare cerebrovascular disease event incidence and risk profiles among the study samples.
resultsThe cumulative, 3-yr incidence of de novo cerebrovascular disease events after transplantation was 6.8% and was lower than adjusted 3-yr estimates of 11.8% on the waiting list and 11.2% after graft loss. In time-dependent regression, transplantation predicted a 34% reduction in subsequent, overall cerebrovascular disease events risk compared with remaining on the waiting list, whereas risk for cerebrovascular disease events increased >150% after graft failure. Similar relationships with transplantation and graft loss were observed for each type of cerebrovascular disease event. Smoking was a potentially preventable correlate of posttransplantation cerebrovascular disease events. Women were not protected. All forms of cerebrovascular disease event diagnoses after transplantation predicted increased mortality.
conclusionsAlong with known benefits for cardiac complications, transplantation with sustained graft function seems to reduce risk for vascular disease events involving the cerebral circulation.
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