ArticleProceedings of the National Academy of Sciences of the United States of America2008
The role of filament-packing dynamics in powering amoeboid cell motility.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Article
- Cytosolic Ca(2+) as a multifunctional modulator is required for spermiogenesis in Ascaris suum.Protein & cell · 2013Article
- Cytoskeletal cross-linking and bundling in motor-independent contraction.Current biology : CB · 2010Review
- Simulation of cell motility that reproduces the force-velocity relationship.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Biochemical mechanisms for regulating protrusion by nematode major sperm protein.Biophysical journal · 2009Article
- Dephosphorylation of major sperm protein (MSP) fiber protein 3 by protein phosphatase 2A during cell body retraction in the MSP-based amoeboid motility of Ascaris sperm.Molecular biology of the cell · 2009Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Although several models have been proposed to account for how cytoskeleton polymerization drives protrusion in cell motility, the precise mechanism remains controversial. Here, we show that, in addition to force exerted directly against the membrane by growing filaments, the way elongating filaments pack also contributes to protrusion by generating an expansion of the cytoskeleton gel. Tomography shows that filament packing in the major sperm protein (MSP) -based nematode sperm-motility machinery resembles that observed with rigid rods. Maximum rod-packing density decreases dramatically as the rods lengthen. Therefore, as filaments elongate, the cytoskeleton gel expands to accommodate their packing less densely. This volume expansion combines with polymerization to drive protrusion. Consistent with this hypothesis, an engineered MSP mutant that generates shorter filaments shows higher filament-packing density and slower movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.