ArticleThe American journal of tropical medicine and hygiene2008
Impaired clinical response in a patient with uncomplicated falciparum malaria who received poor-quality and underdosed intramuscular artemether.
Article in The American journal of tropical medicine and hygiene, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- How patients take malaria treatment: a systematic review of the literature on adherence to antimalarial drugs.PloS one · 2014Pooled it
- Comparison of bioavailability between the most available generic tablet formulation containing artemether and lumefantrine on the Tanzanian market and the innovator's product.Malaria journal · 2013Trial
- Artemisinin resistance in Plasmodium falciparum malaria.The New England journal of medicine · 2009Trial
- A random survey of the prevalence of falsified and substandard antibiotics in the Lao PDR.The Journal of antimicrobial chemotherapy · 2022Article
- Study on identification, assay and organoleptic quality of veterinary medicines in Ethiopia.Journal of pharmaceutical policy and practice · 2022Article
- Potency of commonly retailed antibiotics in pharmacies found in Adama, Oromia regional state, Ethiopia.PloS one · 2021Article
- The quality of malaria care in 25 low-income and middle-income countries.BMJ global health · 2020Article
- Quality of fixed dose artemether/lumefantrine products in Jimma Zone, Ethiopia.Malaria journal · 2019Article
- An Investigation into the Quality of Medicines in Yangon, Myanmar.Pharmacy (Basel, Switzerland) · 2018Article
- Are we doing enough to prevent poor-quality antimalarial medicines in the developing world?BMC public health · 2018Article
- Ethical challenges in designing and conducting medicine quality surveys.Tropical medicine & international health : TM & IH · 2016Article
- Physicochemical equivalence of generic antihypertensive medicines (EQUIMEDS): protocol for a quality of medicines assessment.BMJ global health · 2016Article
- Malaria Diagnosis Across the International Centers of Excellence for Malaria Research: Platforms, Performance, and Standardization.The American journal of tropical medicine and hygiene · 2015Review
- A Repeat Random Survey of the Prevalence of Falsified and Substandard Antimalarials in the Lao PDR: A Change for the Better.The American journal of tropical medicine and hygiene · 2015Article
- Quality of antimalarials at the epicenter of antimalarial drug resistance: results from an overt and mystery client survey in Cambodia.The American journal of tropical medicine and hygiene · 2015Article
- Collaborative health and enforcement operations on the quality of antimalarials and antibiotics in southeast Asia.The American journal of tropical medicine and hygiene · 2015Article
- Estimated under-five deaths associated with poor-quality antimalarials in sub-Saharan Africa.The American journal of tropical medicine and hygiene · 2015Article
- Substandard antimalarials available in Afghanistan: a case for assessing the quality of drugs in resource poor settings.The American journal of tropical medicine and hygiene · 2015Article
- Patient adherence to prescribed artemisinin-based combination therapy in Garissa County, Kenya, after three years of health care in a conflict setting.Malaria journal · 2015Article
- Substandard drugs: a potential crisis for public health.British journal of clinical pharmacology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We describe an adult with uncomplicated Plasmodium falciparum malaria who did not improve clinically despite 5 days of intramuscular artemether therapy. He was prescribed a lower dose (kg body weight) than that recommended, and a vial from the packet contained only 74% of the artemether dose as stated by the manufacturer. The combination of underdosing, poor-quality drug, and the intrinsic low bioavailability of artemether may have contributed to his poor clinical response. Analysis of the packaging and chemical "fingerprinting" of the artemether suggested that the drug was genuine but was either substandard or had deteriorated after manufacture.
Indexed as
Identifiers
18385347PMC7610945W2115417394What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.