ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Subventricular zone-mediated ependyma repair in the adult mammalian brain.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 108 citations in OpenAlex.
- Recurrent pediatric posterior fossa anaplastic ependymoma managed with multiple resections: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Ectopic recruitment of neuroblasts in striatal myelin bundles and nucleus accumbens following AraC chemical lesion.Stem cell reports · 2025Article
- Neurogenesis and glial impairments in congenital hydrocephalus: insights from a BioGlue-induced fetal lamb model.Fluids and barriers of the CNS · 2025Article
- Reversal of Postnatal Brain Astrocytes and Ependymal Cells towards a Progenitor Phenotype in Culture.Cells · 2024Article
- Ventricular-subventricular zone stem cell niche adaptations in a mouse model of post-infectious hydrocephalus.Frontiers in neuroscience · 2024Article
- Formation and function of multiciliated cells.The Journal of cell biology · 2024Review
- Mechanical loading of the ventricular wall as a spatial indicator for periventricular white matter degeneration.Journal of the mechanical behavior of biomedical materials · 2023Article
- Article
- Chromatin accessibility dynamics of neurogenic niche cells reveal defects in neural stem cell adhesion and migration during aging.Nature aging · 2023Article
- Ependyma in Neurodegenerative Diseases, Radiation-Induced Brain Injury and as a Therapeutic Target for Neurotrophic Factors.Biomolecules · 2023Review
- Ependymal cells and neurodegenerative disease: outcomes of compromised ependymal barrier function.Brain communications · 2022Review
- The Subventricular Zone in Glioblastoma: Genesis, Maintenance, and Modeling.Frontiers in oncology · 2022Review
- Isolation of neural stem and oligodendrocyte progenitor cells from the brain of live rats.Stem cell reports · 2021Article
- Optimal Extracellular Matrix Niches for Neurogenesis: Identifying Glycosaminoglycan Chain Composition in the Subventricular Neurogenic Zone.Frontiers in neuroanatomy · 2021Review
- Vascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic Decline.Frontiers in neuroscience · 2021Review
- Syndecan-1 Stimulates Adult Neurogenesis in the Mouse Ventricular-Subventricular Zone after Injury.iScience · 2020Article
- Genetic targeting of neurogenic precursors in the adult forebrain ventricular epithelium.Life science alliance · 2020Article
- The adult human subventricular zone: partial ependymal coverage and proliferative capacity of cerebrospinal fluid.Brain communications · 2020Article
- Heterogeneous Expression of SDF1 Retains Actively Proliferating Neural Progenitors in the Capillary Compartment of the Niche.Stem cell reports · 2019Article
- Calorie restriction protects neural stem cells from age-related deficits in the subventricular zone.Aging · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The subventricular zone (SVZ) of the adult mouse brain is a narrow stem cell niche that lies along the length of the lateral wall of the lateral ventricles. The SVZ supports neurogenesis throughout adulthood; however, with increasing age, the ventral SVZ deteriorates and only the dorsolateral SVZ remains neurogenic. Associated with the elderly dorsolateral SVZ, we reported previously an increased number of astrocytes interposed within the adjacent ependymal lining. Here, we show that astrocytes integrated within the ependyma are dividing, BrdU-labeled astrocytes that share cellular adherens with neighboring ependymal cells. By tracking BrdU-labeled astrocytes over time, we observed that, as they incorporated within the ependyma, they took on antigenic and morphologic characteristics of ependymal cells, suggesting a novel form of SVZ-supported "regenerative" repair in the aging brain. A similar form of SVZ-mediated ependyma repair was also observed in young mice after mild ependymal cell denudation with low dosages of neuraminidase. Together, this work identifies a novel non-neuronal mechanism of regenerative repair by the adult SVZ.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.