ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Artificial synaptic conductances reduce subthreshold oscillations and periodic firing in stellate cells of the entorhinal cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed, 76 citations in OpenAlex.
- Postsynaptic frequency filters shaped by the interplay of synaptic short-term plasticity and cellular time scales.Journal of computational neuroscience · 2025Article
- Heterogeneous stochastic bifurcations explain intrinsic oscillatory patterns in entorhinal cortical stellate cells.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Oscillations and variability in neuronal systems: interplay of autonomous transient dynamics and fast deterministic fluctuations.Journal of computational neuroscience · 2022Article
- The voltage and spiking responses of subthreshold resonant neurons to structured and fluctuating inputs: persistence and loss of resonance and variability.Biological cybernetics · 2022Review
- Article
- Degeneracy in the robust expression of spectral selectivity, subthreshold oscillations, and intrinsic excitability of entorhinal stellate cells.Journal of neurophysiology · 2018Article
- Control of clustered action potential firing in a mathematical model of entorhinal cortex stellate cells.Journal of theoretical biology · 2018Article
- Synaptic integrative mechanisms for spatial cognition.Nature neuroscience · 2017Review
- The shaping of intrinsic membrane potential oscillations: positive/negative feedback, ionic resonance/amplification, nonlinearities and time scales.Journal of computational neuroscience · 2017Article
- Interplay between Subthreshold Oscillations and Depressing Synapses in Single Neurons.PloS one · 2016Article
- Membrane potential-dependent integration of synaptic inputs in entorhinal stellate neurons.Hippocampus · 2014Article
- Frequency preference in two-dimensional neural models: a linear analysis of the interaction between resonant and amplifying currents.Journal of computational neuroscience · 2014Article
- The past, present, and future of real-time control in cellular electrophysiology.IEEE transactions on bio-medical engineering · 2014Review
- How to build a grid cell.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Nonlinear properties of medial entorhinal cortex neurons reveal frequency selectivity during multi-sinusoidal stimulation.Frontiers in cellular neuroscience · 2014Article
- Grid cell firing patterns may arise from feedback interaction between intrinsic rebound spiking and transverse traveling waves with multiple heading angles.Frontiers in systems neuroscience · 2014Article
- Article
- In vivo cholinergic modulation of the cellular properties of medial entorhinal cortex neurons.The Journal of physiology · 2013Article
- Entorhinal stellate cells show preferred spike phase-locking to theta inputs that is enhanced by correlations in synaptic activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Cellular mechanisms of spatial navigation in the medial entorhinal cortex.Nature neuroscience · 2013Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous work has established that stellate cells of the medial entorhinal cortex produce prominent intrinsic subthreshold oscillations in the voltage response concentrated within the theta range (3-7 Hz). It has been speculated that these oscillations play an important role in vivo in establishing network behavior both in the entorhinal cortex and hippocampus. Consequently, it is important to investigate under what conditions theta oscillations in stellate cells can be generated and whether the spike-train power spectral density (PSD) also carries power at theta. We investigated the ability of stellate cells to generate theta oscillations in the presence of generic in vivo-like patterns of stimulation. Inputs were Poisson process-driven excitatory and inhibitory synaptic conductances or currents, introduced via dynamic clamp. We analyzed the subthreshold membrane oscillations and spike-train behavior in the presence of comparable synaptic conductance- or current-mediated membrane fluctuations. In the presence of conductance-based synapses, subthreshold oscillations are highly attenuated or entirely eliminated. Conversely, with current-based synapses stellate cells retain their ability to generate subthreshold oscillations in the theta band. These results also extend into the spiking regime, where only under current-based synapses does the PSD of the spike train show a prominent peak at theta. Furthermore, the peak in the spike-train PSD and spike clustering results from an increased probability of firing after a spike afterhyperpolarization and not directly from subthreshold oscillatory dynamics as has been previously suggested. Our results suggest that subthreshold oscillations may contribute less to in vivo response properties than has been hypothesized.
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