ArticleThe Journal of biological chemistry2008
L-selectin-mediated lymphocyte-cancer cell interactions under low fluid shear conditions.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Dual implication of endothelial adhesion molecules in tumor progression and cancer immunity.Cell adhesion & migration · 2025Review
- Tetraspanin CD9: A friend or foe of head and neck cancer (Review).Oncology reports · 2022Review
- RhoA-ROCK competes with YAP to regulate amoeboid breast cancer cell migration in response to lymphatic-like flow.FASEB bioAdvances · 2022Article
- Identification of α1,2-fucosylated signaling and adhesion molecules in head and neck squamous cell carcinoma.Glycobiology · 2022Article
- The interplay between physical cues and mechanosensitive ion channels in cancer metastasis.Frontiers in cell and developmental biology · 2022Review
- Serum IL-23, E-selectin and sICAM levels in non-small cell lung cancer patients before and after radiotherapy.The Journal of international medical research · 2020Observational
- Nucleolin mediates the binding of cancer cells to L-selectin under conditions of lymphodynamic shear stress.American journal of physiology. Cell physiology · 2020Article
- Dynamic biochemical tissue analysis detects functional selectin ligands on human cancer tissues.Scientific reports · 2019Article
- Fluid shear stress activates YAP1 to promote cancer cell motility.Nature communications · 2017Article
- Pathobiological implications of mucin glycans in cancer: Sweet poison and novel targets.Biochimica et biophysica acta · 2015Review
- Generation of shear adhesion map using SynVivo synthetic microvascular networks.Journal of visualized experiments : JoVE · 2014Article
- Aberrant glycosylation in the human trabecular meshwork.Proteomics. Clinical applications · 2014Article
- WMAXC: a weighted maximum clique method for identifying condition-specific sub-network.PloS one · 2014Article
- Tumor necrosis factor-alpha-converting enzyme activities and tumor-associated macrophages in breast cancer.Immunologic research · 2014Review
- Anti-metastasis effect of fucoidan from Undaria pinnatifida sporophylls in mouse hepatocarcinoma Hca-F cells.PloS one · 2014Article
- Simultaneously capturing real-time images in two emission channels using a dual camera emission splitting system: applications to cell adhesion.Journal of visualized experiments : JoVE · 2013Article
- Inflammatory status of transmigrating primary rat monocytes in a novel perfusion model simulating blood flow.Journal of neuroimmunology · 2013Article
- Computational and experimental models of cancer cell response to fluid shear stress.Frontiers in oncology · 2013Article
- Laminin interactions with head and neck cancer cells under low fluid shear conditions lead to integrin activation and binding.The Journal of biological chemistry · 2012Article
- Subcellular localization of L-selectin ligand in the endometrium implies a novel function for pinopodes in endometrial receptivity.Reproductive biology and endocrinology : RB&E · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Cell migration in blood flow is mediated by engagement of specialized adhesion molecules that function under hemodynamic shear conditions, and many of the effectors of these adhesive interactions, such as the selectins and their ligands, are well defined. However, in contrast, our knowledge of the adhesion molecules operant under lymphatic flow conditions is incomplete. Among human malignancies, head and neck squamous cell cancer displays a marked predilection for locoregional lymph node metastasis. Based on this distinct tropism, we hypothesized that these cells express adhesion molecules that promote their binding to lymphoid tissue under lymphatic fluid shear stress. Accordingly, we investigated adhesive interactions between these and other cancer cells and the principal resident cells of lymphoid organs, lymphocytes. Parallel plate flow chamber studies under defined shear conditions, together with biochemical analyses, showed that human head and neck squamous cell cancer cells express heretofore unrecognized L-selectin ligand(s) that mediate binding to lymphocyte L-selectin at conspicuously low shear stress levels of 0.07-0.08 dynes/cm(2), consistent with lymphatic flow. The binding of head and neck squamous cancer cells to L-selectin displays canonical biochemical features, such as requirements for sialylation, sulfation, and N-glycosylation, but displays a novel operational shear threshold differing from all other L-selectin ligands, including those expressed on colon cancer and leukemic cells (e.g. HCELL). These data define a novel class of L-selectin ligands and expand the scope of function for L-selectin within circulatory systems to now include a novel activity within shear stresses characteristic of lymphatic flow.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.