ReviewGenetics2008
Probing the relative importance of molecular oscillations in the circadian clock.
Review in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 116 citations in OpenAlex.
- Experimentally Guided Iterative Parameter Estimation for Predictive Chemical Oscillator Models.Angewandte Chemie (International ed. in English) · 2025Article
- The genetically programmed rhythmic alteration of diurnal gene expression in the agedFrontiers in plant science · 2024Article
- Perfecting the Life Clock: The Journey from PTO to TTFL.International journal of molecular sciences · 2023Review
- Regulation of circadian rhythm and sleep by miR-375-timeless interaction in Drosophila.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- TIMELESS regulates sphingolipid metabolism and tumor cell growth through Sp1/ACER2/S1P axis in ER-positive breast cancer.Cell death & disease · 2020Article
- Melatonin Relations with Energy Metabolism as Possibly Involved in Fatal Mountain Road Traffic Accidents.International journal of molecular sciences · 2020Review
- Article
- Photosensitive Alternative Splicing of the Circadian Clock GeneG3 (Bethesda, Md.) · 2018Article
- Non-Pleiotropic Coupling of Daily and Seasonal Temporal Isolation in the European Corn Borer.Genes · 2018Article
- Elements of biological oscillations in time and space.Nature structural & molecular biology · 2016Article
- PDF Signaling Is an Integral Part of the Drosophila Circadian Molecular Oscillator.Cell reports · 2016Article
- Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila.Cell metabolism · 2016Article
- Class IIa histone deacetylases are conserved regulators of circadian function.The Journal of biological chemistry · 2014Article
- Adaptive evolution of the circadian gene timeout in insects.Scientific reports · 2014Article
- N-acetyltransferase (nat) is a critical conjunct of photoperiodism between the circadian system and endocrine axis in Antheraea pernyi.PloS one · 2014Article
- Notch4-dependent antagonism of canonical TGF-β1 signaling defines unique temporal fluctuations of SMAD3 activity in sheared proximal tubular epithelial cells.American journal of physiology. Renal physiology · 2013Article
- Circadian rhythms and period expression in the Hawaiian cricket genus Laupala.Behavior genetics · 2013Article
- Review
- Extensive circadian and light regulation of the transcriptome in the malaria mosquito Anopheles gambiae.BMC genomics · 2013Article
- Nature's Timepiece-Molecular Coordination of Metabolism and Its Impact on Aging.International journal of molecular sciences · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Circadian ( approximately 24 hr) rhythms of behavior and physiology are driven by molecular clocks that are endogenous to most organisms. The mechanisms underlying these clocks are remarkably conserved across evolution and typically consist of auto-regulatory loops in which specific proteins (clock proteins) rhythmically repress expression of their own genes. Such regulation maintains 24-hr cycles of RNA and protein expression. Despite the conservation of these mechanisms, however, questions are now being raised about the relevance of different molecular oscillations. Indeed, several studies have demonstrated that oscillations of some critical clock genes can be eliminated without loss of basic clock function. Here, we describe the multiple levels at which clock gene/protein expression and function can be rhythmically regulated-transcription, protein expression, post-translational modification, and localization-and speculate as to which aspect of this regulation is most critical. While the review is focused on Drosophila, we include some discussion of mammalian clocks to indicate the extent to which the questions concerning clock mechanisms are similar, regardless of the organism under study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.