ArticleInternational journal of pharmaceutics2008
Cationic lipid-coated magnetic nanoparticles associated with transferrin for gene delivery.
Article in International journal of pharmaceutics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Paclitaxel-Loaded Lipid-Coated Magnetic Nanoparticles for Dual Chemo-Magnetic Hyperthermia Therapy of Melanoma.Pharmaceutics · 2023Article
- Synthesis and characterization of magnetic nanoparticles coated with polystyrene sulfonic acid for biomedical applications.Science and technology of advanced materials · 2020Article
- Nanoparticle encapsulation increases the brain penetrance and duration of action of intranasal oxytocin.Hormones and behavior · 2019Article
- Nanoparticle formulations that allow for sustained delivery and brain targeting of the neuropeptide oxytocin.International journal of pharmaceutics · 2018Article
- Molecular design of upconversion nanoparticles for gene delivery.Chemical science · 2017Review
- Enriching Nanoparticles via Acoustofluidics.ACS nano · 2017Article
- Generation of Transgenic Porcine Fibroblast Cell Lines Using Nanomagnetic Gene Delivery Vectors.Molecular biotechnology · 2016Article
- Magnetite nanostructures as novel strategies for anti-infectious therapy.Molecules (Basel, Switzerland) · 2014Review
- Functional magnetic nanoparticles for non-viral gene delivery and MR imaging.Pharmaceutical research · 2014Review
- Development of a novel lipophilic, magnetic nanoparticle for in vivo drug delivery.Pharmaceutics · 2013Article
- Article
- A review of RGD-functionalized nonviral gene delivery vectors for cancer therapy.Cancer gene therapy · 2012Review
- Transferrin adsorption onto PLGA nanoparticles governs their interaction with biological systems from blood circulation to brain cancer cells.Pharmaceutical research · 2012Article
- Acceleration of gene transfection efficiency in neuroblastoma cells through polyethyleneimine/poly(methyl methacrylate) core-shell magnetic nanoparticles.International journal of nanomedicine · 2012Article
- Solid lipid nanoparticles loaded with anti-microRNA oligonucleotides (AMOs) for suppression of microRNA-21 functions in human lung cancer cells.Pharmaceutical research · 2012Article
- Magnetically enhanced nucleic acid delivery. Ten years of magnetofection-progress and prospects.Advanced drug delivery reviews · 2011Review
- Click assembly of magnetic nanovectors for gene delivery.Biomaterials · 2011Article
- Magnetic nanoparticles as targeted delivery systems in oncology.Radiology and oncology · 2011Article
- Application of magnetic nanoparticles to gene delivery.International journal of molecular sciences · 2011Review
- Iron oxide-based nanomagnets in nanomedicine: fabrication and applications.Nano reviews · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Cationic lipid-coated magnetic nanoparticles (MPs) associated with transferrin were evaluated as gene transfer vectors in the presence of a static magnetic field. MPs were prepared by chemical precipitation and were surface-coated with cationic lipids, composed of DDAB/soy PC (60:40 mole/mole). These cationic MPs were then combined with polyethylenimine (PEI) condensed plasmid DNA, followed by transferrin. The resulting magnetic electrostatic complexes retained relatively compact particle size and showed complete DNA condensation. Their transfection activity in the presence of a static magnetic field was evaluated by luciferase and green fluorescent protein (GFP) reporter genes. The magnetic complexes exhibited up to 300-fold higher transfection activity compared to commonly used cationic liposomes or cationic polymer complexes, based on luciferase assay. The enhancement in transfection activity was maximized when the cells were exposed to the vectors for a relatively short period of time (15 min), or were treated in media containing 10% serum. Incorporation of transferrin further improved transfection efficiency of the cationic MPs. However, when cells were incubated for 4h in serum-free media, magnetic and non-magnetic vectors showed similar transfection efficiencies. In conclusion, transferrin-associated cationic MPs are excellent gene transfer vectors that can mediate very rapid and efficient gene transfer in vitro in the presence of a magnetic field.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.