ArticleDrug and alcohol dependence2008
Association of candidate genes with antisocial drug dependence in adolescents.
Article in Drug and alcohol dependence, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Genetic and environmental influences on psychiatric comorbidity: a systematic review.Journal of affective disorders · 2010Pooled it
- Theorizing the Role of Dopaminergic Polymorphic Risk Alleles with Intermittent Explosive Disorder (IED), Violent/Aggressive Behavior and Addiction: Justification of Genetic Addiction Risk Severity (GARS) Testing.Journal of personalized medicine · 2022Article
- Detection of Parent-of-Origin Effects for the Variants Associated With Behavioral Disinhibition in the MCTFR Data.Frontiers in genetics · 2022Article
- Adolescent Intermittent Ethanol (AIE) Enhances the Dopaminergic Response to Ethanol within the Mesolimbic Pathway during Adulthood: Alterations in Cholinergic/Dopaminergic Genes Expression in the Nucleus Accumbens Shell.International journal of molecular sciences · 2021Article
- Genetic susceptibility of opioid receptor genes polymorphism to drug addiction: A candidate-gene association study.BMC psychiatry · 2021Article
- Cannabis Constituents and Acetylcholinesterase Interaction: Molecular Docking, In Vitro Studies and Association withBiomolecules · 2020Article
- Article
- Haplotype-Based Association and In Silico Studies of OPRM1 Gene Variants with Susceptibility to Opioid Dependence Among Addicted Iranians Undergoing Methadone Treatment.Journal of molecular neuroscience : MN · 2020Article
- Genome-wide association study implicates CHRNA2 in cannabis use disorder.Nature neuroscience · 2019Article
- Article
- Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin.Pharmacogenomics · 2018Article
- Insights Into Nicotinic Receptor Signaling in Nicotine Addiction: Implications for Prevention and Treatment.Current neuropharmacology · 2018Review
- Genetic influences on adolescent behavior.Neuroscience and biobehavioral reviews · 2016Review
- Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence.Behavior genetics · 2016Article
- A signal peptide missense mutation associated with nicotine dependence alters α2*-nicotinic acetylcholine receptor function.Neuropharmacology · 2014Article
- Transdiagnostic and disorder-specific models of intergenerational transmission of internalizing pathology.Psychological medicine · 2014Article
- A genome-wide association study of behavioral disinhibition.Behavior genetics · 2013Article
- Targeted deletion of the mouse α2 nicotinic acetylcholine receptor subunit gene (Chrna2) potentiates nicotine-modulated behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The Colorado Adoption Project.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2013Article
- The genetics of addiction-a translational perspective.Translational psychiatry · 2012Review
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
The Colorado Center For Antisocial Drug Dependence (CADD) is using several research designs and strategies in its study of the genetic basis for antisocial drug dependence in adolescents. This study reports single nucleotide polymorphism (SNP) association results from a targeted gene assay (SNP chip) of 231 primarily Caucasian male probands in treatment with antisocial drug dependence and a matched set of community controls. The SNP chip was designed to assay 1500 SNPs distributed across 50 candidate genes that have had associations with substance use disorders and conduct disorder. There was an average gene-wide inter-SNP interval of 3000 base pairs. After eliminating SNPs with poor signals and low minor allele frequencies, 60 nominally significant associations were found among the remaining 1073 SNPs in 18 of 49 candidate genes. Although none of the SNPs achieved genome-wide association significance levels (defined as p<.000001), two genes probed with multiple SNPs (OPRM1 and CHRNA2) emerged as plausible candidates for a role in antisocial drug dependence after gene-based permutation tests. The custom-designed SNP chip served as an effective and flexible platform for rapid interrogation of a large number of plausible candidate genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.