Evidence map›Paper›PMID 18384919›Full record

ArticleVaccine2008

Protection of chickens against avian influenza with non-replicating adenovirus-vectored vaccine.

Haroldo Toro, De-chu C Tang, David L Suarez, Jianfeng Zhang, Zhongkai Shi

Open access · greenAbstract read
In one paragraph

Article in Vaccine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Viral vector-based influenza vaccines.Human vaccines & immunotherapeutics · 2016
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Development of adenoviral vector-based mucosal vaccine against influenza.Journal of molecular medicine (Berlin, Germany) · 2011
    Review
  8. Review
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Haroldo ToroDepartment of Pathobiology, Auburn University, Auburn, AL 36849, USA. torohar@auburn.edu
De-chu C Tang
David L Suarez
Jianfeng Zhang
Zhongkai Shi
Auburn University · USU.S. National Poultry Research Center · US

Funding

In-ovo vaccination/avian influenza/bird/humanR43AI068285 · NIAID · VAXIN INC. · PI TANG, DE-CHU CHRISTOPHER · 2006 to 2006
$112k
NIAID NIH HHS 1R43 AI 068285-01NIAID NIH HHS R43 AI068285
6 · The paper itself

Abstract

Protective immunity against avian influenza (AI) virus was elicited in chickens by single-dose vaccination with a replication competent adenovirus (RCA)-free human adenovirus (Ad) vector encoding an H7 AI hemagglutinin (AdChNY94.H7). Chickens vaccinated in ovo with an Ad vector encoding an AI H5 (AdTW68.H5) previously described, which were subsequently vaccinated intramuscularly with AdChNY94.H7 post-hatch, responded with robust antibody titers against both the H5 and H7 AI proteins. Antibody responses to Ad vector in ovo vaccination follow a dose-response kinetic. The use of a synthetic AI H5 gene codon optimized to match the chicken cell tRNA pool was more potent than the cognate H5 gene. The use of Ad-vectored vaccines to increase resistance of chicken populations against multiple AI strains could reduce the risk of an avian-originating influenza pandemic in humans.

Indexed as

Genetic VectorsAdenoviridaeAnimalsAntibodies, ViralChickensDose-Response Relationship, ImmunologicHemagglutinin Glycoproteins, Influenza VirusInfluenza in BirdsInfluenza VaccinesPharynxAntibodies, Viralhemagglutinin, avian influenza A virusHemagglutinin Glycoproteins, Influenza VirusInfluenza Vaccines

Identifiers

PMID18384919
PMCPMC2720404
OpenAlexW2067064533

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.