ReviewProgress in biophysics and molecular biology
Cell cultures as models of cardiac mechanoelectric feedback.
Review in Progress in biophysics and molecular biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Structural and functional benchmarking of monolayer- and bioreactor-generated hiPSC-derived cardiomyocytes.APL bioengineering · 2026Article
- Novel Optics-Based Approaches for Cardiac Electrophysiology: A Review.Frontiers in physiology · 2021Review
- Discriminating aspects of global metabolism of neonatal cardiomyocytes from wild type and KO-CSRP3 rats using proton magnetic resonance spectroscopy of culture media samples.In vitro cellular & developmental biology. Animal · 2020Article
- Myocardial slices come to age: an intermediate complexity in vitro cardiac model for translational research.Cardiovascular research · 2020Review
- Magnetic Resonance Imaging of Contracting Ultrathin Cardiac Tissue.Biomedical physics & engineering express · 2019Article
- Differential Mechanisms of Myocardial Conduction Slowing by Adipose Tissue-Derived Stromal Cells Derived from Different Species.Stem cells translational medicine · 2017Article
- Model of Human Fetal Growth in Hypoplastic Left Heart Syndrome: Reduced Ventricular Growth Due to Decreased Ventricular Filling and Altered Shape.Frontiers in pediatrics · 2017Article
- Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.Circulation research · 2016Review
- Increased cell membrane capacitance is the dominant mechanism of stretch-dependent conduction slowing in the rabbit heart: a computational study.Cellular and molecular bioengineering · 2015Article
- Caveolae in ventricular myocytes are required for stretch-dependent conduction slowing.Journal of molecular and cellular cardiology · 2014Article
- Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse model.Human molecular genetics · 2014Article
- Biomechanics of cardiac electromechanical coupling and mechanoelectric feedback.Journal of biomechanical engineering · 2014Review
- Structural and functional plasticity in long-term cultures of adult ventricular myocytes.Journal of molecular and cellular cardiology · 2013Article
- Shear stress triggers insertion of voltage-gated potassium channels from intracellular compartments in atrial myocytes.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Mechanobiology of cardiomyocyte development.Journal of biomechanics · 2010Review
- The zebrafish as a novel animal model to study the molecular mechanisms of mechano-electrical feedback in the heart.Progress in biophysics and molecular biologyArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Although stretch-activated currents have been extensively studied in isolated cells and intact heart in the context of mechanoelectric feedback (MEF) in the heart, quantitative data regarding other mechanical parameters such as pressure, shear, bending, etc, are still lacking at the multicellular level. Cultured cardiac cell monolayers have been used increasingly in the past decade as an in vitro model for the studies of fundamental mechanisms that underlie normal and pathological electrophysiology at the tissue level. Optical mapping makes possible multisite recording and analysis of action potentials and wavefront propagation, suitable for monitoring the electrophysiological activity of the cardiac cell monolayer under a wide variety of controlled mechanical conditions. In this paper, we review methodologies that have been developed or could be used to mechanically perturb cell monolayers, and present some new results on the acute effects of pressure, shear stress and anisotropic strain on cultured neonatal rat ventricular myocyte (NRVM) monolayers.
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