ArticleBMC cancer2008
The assessment of angiogenesis and fibroblastic stromagenesis in hyperplastic and pre-invasive breast lesions.
Article in BMC cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- Allogeneic Immune Cell Perfusion Inhibits the Growth of Vascularized 3D In Vitro Tumor Models, Induces Vascular Regression and Desmoplasia, but Promotes Tumor Cell Invasion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Complex Path from Mammary Ductal Hyperplasia to Breast Cancer: Elevated Malignancy Risk in Atypical Forms.Biomedicines · 2026Review
- The emerging role of photoacoustic imaging in clinical oncology.Nature reviews. Clinical oncology · 2022Review
- Optoacoustic imaging of the breast: correlation with histopathology and histopathologic biomarkers.European radiology · 2019Article
- Iron in the Tumor Microenvironment-Connecting the Dots.Frontiers in oncology · 2018Review
- High expression of intratumoral stromal proteins is associated with chemotherapy resistance in breast cancer.Oncotarget · 2016Article
- Relationships between mammographic density, tissue microvessel density, and breast biopsy diagnosis.Breast cancer research : BCR · 2016Article
- β1-Integrin via NF-κB signaling is essential for acquisition of invasiveness in a model of radiation treated in situ breast cancer.Breast cancer research : BCR · 2013Article
- Neuropilins: expression and roles in the epithelium.International journal of experimental pathology · 2012Review
- Microvessel Density Is Associated with VEGF and α-SMA Expression in Different Regions of Human Gastrointestinal Carcinomas.Cancers · 2011Article
- Angiogenesis in the progression of breast ductal proliferations.International journal of surgical pathology · 2011Article
- The benefits and challenges associated with the use of drug delivery systems in cancer therapy.Biochemical pharmacology · 2010Review
- Analysis of stromal signatures in the tumor microenvironment of ductal carcinoma in situ.Breast cancer research and treatment · 2010Article
- Vasohibin-1 as a potential predictor of aggressive behavior of ductal carcinoma in situ of the breast.Cancer science · 2010Article
- Serum protein signature may improve detection of ductal carcinoma in situ of the breast.Oncogene · 2010Article
- Angiogenesis and breast cancer.Journal of oncology · 2010Article
- Antiangiogenic therapies in early-stage breast cancer.Clinical breast cancer · 2010Review
- Fibroblasts in three dimensional matrices: cell migration and matrix remodeling.Experimental & molecular medicine · 2009Review
- A taxonomy of epithelial human cancer and their metastases.BMC medical genomics · 2009Article
- Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ.Cancer research · 2009Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the changes of the neoplastic microenvironment during the different morphological alterations of hyperplastic and pre-invasive breast lesions.
methods78 in situ ductal carcinomas of all degrees of differentiation, 22 atypical ductal hyperplasias, 25 in situ lobular carcinomas, 18 atypical lobular hyperplasias, 32 ductal epithelial hyperplasias of usual type and 8 flat atypias were immunohistochemically investigated for the expression of vascular endothelial growth factor (VEGF), smooth muscle actin (SMA) and CD34, while microvessel density (MVD) was counted using the anti-CD31 antibody.
resultsVEGF expression was strongly correlated with MVD in all hyperplastic and pre-invasive breast lesions (p < 0.05). Stromagenesis, as characterized by an increase in SMA and a decrease in CD34 positive myofibroblasts was observed mostly around ducts harboring high grade in situ carcinoma and to a lesser extent around moderately differentiated DCIS. In these two groups of in situ carcinomas, a positive correlation between MVD and SMA (p < 0.05) was observed. On the contrary, CD34 was found to be inversely related to MVD (p < 0.05). No statistically significant changes of the stromal fibroblasts were observed in low grade DCIS neither in any of the other lesions under investigation as compared to normal mammary intra- and interlobular stroma.
conclusionAngiogenesis is observed before any significant fibroblastic stromagenesis in pre-invasive breast lesions. A composite phenotype characterized by VEGF positive epithelial cells and SMA positive/CD34 negative stromal cells, is identified mostly in intermediate and high grade DCIS. These findings might imply for new therapeutic strategies using both anti-angiogenic factors and factors selectively targeting tumor stroma in order to prevent the progression of DCIS to invasive carcinoma.
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