ArticleBioscience reports2008
Stimulation of mitochondrial proton conductance by hydroxynonenal requires a high membrane potential.
Article in Bioscience reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 66 citations in OpenAlex.
- Mitochondrial dysfunction is a hallmark of woody breast myopathy in broiler chickens.Frontiers in physiology · 2025Article
- Muscle Oxidative Stress Plays a Role in Hyperthyroidism-Linked Insulin Resistance.Antioxidants (Basel, Switzerland) · 2023Article
- Nitric oxide regulation of cellular metabolism: Adaptive tuning of cellular energy.Nitric oxide : biology and chemistry · 2023Review
- Induction of beige-like adipocyte markers and functions in 3T3-L1 cells by Clk1 and PKCβII inhibitory molecules.Journal of cellular and molecular medicine · 2022Article
- Pros and cons for the evidence of adaptive non-shivering thermogenesis in marsupials.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Review
- Combined administration of lauric acid and glucose improved cancer-derived cardiac atrophy in a mouse cachexia model.Cancer science · 2020Article
- Molecular Changes Induced by Oxidative Stress that Impair Human Sperm Motility.Antioxidants (Basel, Switzerland) · 2020Review
- The Role of Phosphatidylethanolamine Adducts in Modification of the Activity of Membrane Proteins under Oxidative Stress.Molecules (Basel, Switzerland) · 2019Review
- Proton leak regulates mitochondrial reactive oxygen species generation in endothelial cell activation and inflammation - A novel concept.Archives of biochemistry and biophysics · 2019Review
- Effect of lithocholic acid on biologically active α,β-unsaturated aldehydes induced by H2O2 in glioma mitochondria for use in glioma treatment.International journal of molecular medicine · 2018Article
- Mitochondrial Proton Leak Plays a Critical Role in Pathogenesis of Cardiovascular Diseases.Advances in experimental medicine and biology · 2017Review
- Mitochondrial Respiration in Human Colorectal and Breast Cancer Clinical Material Is Regulated Differently.Oxidative medicine and cellular longevity · 2017Article
- The molecular mechanism behind reactive aldehyde action on transmembrane translocations of proton and potassium ions.Free radical biology & medicine · 2015Article
- Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis.American journal of physiology. Endocrinology and metabolism · 2015Article
- Teaching the fundamentals of electron transfer reactions in mitochondria and the production and detection of reactive oxygen species.Redox biology · 2015Review
- UCP2, a mitochondrial protein regulated at multiple levels.Cellular and molecular life sciences : CMLS · 2014Review
- Site-specific antioxidative therapy for prevention of atherosclerosis and cardiovascular disease.Oxidative medicine and cellular longevity · 2013Review
- Fatty acids are key in 4-hydroxy-2-nonenal-mediated activation of uncoupling proteins 1 and 2.PloS one · 2013Article
- Hydroxynonenal, a lipid peroxidation end product, stimulates uncoupling protein activity in Acanthamoeba castellanii mitochondria; the sensitivity of the inducible activity to purine nucleotides depends on the membranous ubiquinone redox state.Journal of bioenergetics and biomembranes · 2012Article
- Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy.American journal of physiology. Heart and circulatory physiology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Mild uncoupling of oxidative phosphorylation, caused by a leak of protons back into the matrix, limits mitochondrial production of ROS (reactive oxygen species). This proton leak can be induced by the lipid peroxidation products of ROS, such as HNE (4-hydroxynonenal). HNE activates uncoupling proteins (UCP1, UCP2 and UCP3) and ANT (adenine nucleotide translocase), thereby providing a negative feedback loop. The mechanism of activation and the conditions necessary to induce uncoupling by HNE are unclear. We have found that activation of proton leak by HNE in rat and mouse skeletal muscle mitochondria is dependent on incubation with respiratory substrate. In the presence of HNE, mitochondria energized with succinate became progressively more leaky to protons over time compared with mitochondria in the absence of either HNE or succinate. Energized mitochondria must attain a high membrane potential to allow HNE to activate uncoupling: a drop of 10-20 mV from the resting value is sufficient to blunt induction of proton leak by HNE. Uncoupling occurs through UCP3 (11%), ANT (64%) and other pathways (25%). Our findings have shown that exogenous HNE only activates uncoupling at high membrane potential. These results suggest that both endogenous HNE production and high membrane potential are required before mild uncoupling will be triggered to attenuate mitochondrial ROS production.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.