ReviewThe Journal of clinical investigation2008
Helminth infections: the great neglected tropical diseases.
Review in The Journal of clinical investigation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 764 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
764 citing papers in PubMed, 6 syntheses or guidelines pooled it, 1,568 citations in OpenAlex.
- A systematic review and meta-analysis on the global prevalence of helminthic parasites among schoolchildren: a public health concern.BMC public health · 2025Pooled it
- Prevalence and correlates of soil-transmitted helminths in schoolchildren aged 5 to 18 years in low- and middle-income countries: a systematic review and meta-analysis.Frontiers in public health · 2024Pooled it
- Metabolomics and lipidomics studies of parasitic helminths: molecular diversity and identification levels achieved by using different characterisation tools.Metabolomics : Official journal of the Metabolomic Society · 2023Pooled it
- Effects of helminths and anthelmintic treatment on cardiometabolic diseases and risk factors: A systematic review.PLoS neglected tropical diseases · 2023Pooled it
- Historical overview and geographical distribution of neglected tropical diseases amenable to preventive chemotherapy in the Republic of the Congo: A systematic review.PLoS neglected tropical diseases · 2022Pooled it
- Prevalence of soil-transmitted helminths infections among preschool and school-age children in Ethiopia: a systematic review and meta-analysis.Global health research and policy · 2022Pooled it
- Effectiveness of a School Intervention Based on Knowledge, Attitude, and Practice of Soil-Transmitted Helminths.The American journal of tropical medicine and hygiene · 2024Trial
- How important is the spatial movement of people in attempts to eliminate the transmission of human helminth infections by mass drug administration?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Trial
- Trial
- Factors associated with the fertility of the helminth parasiteFood and waterborne parasitology · 2026Article
- From infection to cholangiocarcinoma: Why opisthorchiids break these rules.One health (Amsterdam, Netherlands) · 2026Review
- Automated detection and classification of intestinal protozoan cysts using a nuclei structure-based deep learning framework for epidemiological surveillance.Parasite epidemiology and control · 2026Article
- Effects of Three Anthelmintics on the Transcriptome of FHs 74 Int Enterocytes.Tropical medicine and infectious disease · 2026Article
- Trichinella spiralis infection remodels intestinal neurotransmitter metabolism during LPS-induced systemic inflammation.Food and waterborne parasitology · 2026Article
- Estimation of the global burden of tungiasis in endemic countries using a disability adjusted life-years modelling approach.BMC global and public health · 2026Article
- Coinfection with Giardiasis and Taeniasis.The American journal of tropical medicine and hygiene · 2026Article
- Structural and evolutionary insights into DAF-12 interactions with transcriptional coactivators in parasitic nematodes.PLoS pathogens · 2026Article
- Article
- From conventional to biosensor-based detection ofFood and waterborne parasitology · 2026Review
- Evaluation of the diagnostic capacity for neglected tropical diseases in a refugee settlement in Uganda: a cross-sectional study.Tropical medicine and health · 2026Article
704 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helminths are parasitic worms. They are the most common infectious agents of humans in developing countries and produce a global burden of disease that exceeds better-known conditions, including malaria and tuberculosis. As we discuss here, new insights into fundamental helminth biology are accumulating through newly completed genome projects and the nascent application of transgenesis and RNA interference technologies. At the same time, our understanding of the dynamics of the transmission of helminths and the mechanisms of the Th2-type immune responses that are induced by infection with these parasitic worms has increased markedly. Ultimately, these advances in molecular and medical helminth biology should one day translate into a new and robust pipeline of drugs, diagnostics, and vaccines for targeting parasitic worms that infect humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.