Evidence map›Paper›PMID 18382741›Full record

ReviewThe Journal of clinical investigation2008

Pneumonia research to reduce childhood mortality in the developing world.

J Anthony G Scott, W Abdullah Brooks, J S Malik Peiris, Douglas Holtzman, E Kim Mulholland

Registry-linked trialAbstract readReview
In one paragraph

Review in The Journal of clinical investigation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01443117 (Administration of Polysaccharide or Conjugated Pneumococcal Vaccines to HIV-Infected Pregnant Women), which is not on this map. Cited by 72 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01443117 phase2withdrawnnot on this map

Administration of Polysaccharide or Conjugated Pneumococcal Vaccines to HIV-Infected Pregnant Women: Safety and Magnitude, Persistence, and Transplacental Transfer of Vaccine-Serotype Pneumococcal Anti-Capsular Antibodies

TypeinterventionalSponsorNational Institute of Allergy and Infectious Diseases (NIAID)Enrolled0ConditionsPneumococcal Infections, HIV InfectionsArmsPPV-23 Vaccine, PCV-13 Vaccine, Placebo Vaccine
3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. The association between bacteria colonizing the upper respiratory tract and lower respiratory tract infection in young children: a systematic review and meta-analysis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2021
    Pooled it
  2. Guideline
  3. Trial
  4. Hydrogel applications: a promising frontier in pneumonia therapy.Frontiers in bioengineering and biotechnology · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Lectin andMolecules (Basel, Switzerland) · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

J Anthony G ScottWellcome Trust/KEMRI Research Programme, Kilifi, Kenya. ascott@ikikifi.net
W Abdullah Brooks
J S Malik Peiris
Douglas Holtzman
E Kim Mulholland

Funding

Wellcome Trust 061089Wellcome Trust 081835
6 · The paper itself

Abstract

Pneumonia is an illness, usually caused by infection, in which the lungs become inflamed and congested, reducing oxygen exchange and leading to cough and breathlessness. It affects individuals of all ages but occurs most frequently in children and the elderly. Among children, pneumonia is the most common cause of death worldwide. Historically, in developed countries, deaths from pneumonia have been reduced by improvements in living conditions, air quality, and nutrition. In the developing world today, many deaths from pneumonia are also preventable by immunization or access to simple, effective treatments. However, as we highlight here, there are critical gaps in our understanding of the epidemiology, etiology, and pathophysiology of pneumonia that, if filled, could accelerate the control of pneumonia and reduce early childhood mortality.

Indexed as

Developing CountriesAnimalsBacterial VaccinesBronchiolitisChildHumansPneumoniaStreptococcus pneumoniaeBacterial Vaccines

Identifiers

PMID18382741
PMCPMC2276784

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.