ReviewThe Journal of clinical investigation2008
Enteric infections, diarrhea, and their impact on function and development.
Review in The Journal of clinical investigation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01704105 (WASH Benefits Kenya), which is not on this map. Cited by 216 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
WASH Benefits Kenya: A Cluster Randomized Controlled Trial of the Benefits of Sanitation, Water Quality, Handwashing, and Nutrition Interventions on Child Health and Development
Who cites it
216 citing papers in PubMed, 9 syntheses or guidelines pooled it, 493 citations in OpenAlex.
- Effectiveness of domestic food hygiene interventions on the microbiological quality of child food and childhood diarrhoea: a systematic review and meta-analysis.BMJ global health · 2026Pooled it
- Disease burden of norovirus-associated diarrhea among children under 5 years old in China: a meta-analysis.BMC infectious diseases · 2025Pooled it
- Disease burden of rotavirus related diarrhea in children under 5 years in China: a meta-analysis.Scientific reports · 2025Pooled it
- Epidemiology of Rotavirus in Humans, Animals, and the Environment in Africa: A Systematic Review and Meta-analysis.The Journal of infectious diseases · 2024Pooled it
- Water, sanitation and hygiene interventions and the prevention and treatment of childhood acute malnutrition: A systematic review.Maternal & child nutrition · 2022Pooled it
- Early life risk factors of motor, cognitive and language development: a pooled analysis of studies from low/middle-income countries.BMJ open · 2019Pooled it
- Effects of single and combined water, sanitation and hygiene (WASH) interventions on nutritional status of children: a systematic review and meta-analysis.Italian journal of pediatrics · 2019Pooled it
- A genome-wide association meta-analysis of diarrhoeal disease in young children identifies FUT2 locus and provides plausible biological pathways.Human molecular genetics · 2016Pooled it
- Interventions to improve disposal of human excreta for preventing diarrhoea.The Cochrane database of systematic reviews · 2010Pooled it
- Trial
- Consequences of post-discharge hospitalisation on the growth of young Bangladeshi children hospitalised with diarrhoea: a secondary case-control analysis of Antibiotics for Children with Diarrhea (ABCD) trial.Journal of global health · 2025Trial
- Characteristics and outcomes of children 2-23 months of age with prolonged diarrhoea: A secondary analysis of data from the 'Antibiotics for Children with Diarrhea' trial.Journal of global health · 2024Trial
- Trial
- Trial
- Stunted childhood growth is associated with decompartmentalization of the gastrointestinal tract and overgrowth of oropharyngeal taxa.Proceedings of the National Academy of Sciences of the United States of America · 2018Trial
- Village sanitation and child health: Effects and external validity in a randomized field experiment in rural India.Journal of health economics · 2016Trial
- Diarrhea, stimulation and growth predict neurodevelopment in young North Indian children.PloS one · 2015Trial
- The oral, live attenuated enterotoxigenic Escherichia coli vaccine ACE527 reduces the incidence and severity of diarrhea in a human challenge model of diarrheal disease.Clinical and vaccine immunology : CVI · 2012Trial
- A combination vaccine consisting of three live attenuated enterotoxigenic Escherichia coli strains expressing a range of colonization factors and heat-labile toxin subunit B is well tolerated and immunogenic in a placebo-controlled double-blind phase I trial in healthy adults.Clinical and vaccine immunology : CVI · 2011Trial
- Early weaning increases diarrhea morbidity and mortality among uninfected children born to HIV-infected mothers in Zambia.The Journal of infectious diseases · 2011Trial
156 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Enteric infections, with or without overt diarrhea, have profound effects on intestinal absorption, nutrition, and childhood development as well as on global mortality. Oral rehydration therapy has reduced the number of deaths from dehydration caused by infection with an enteric pathogen, but it has not changed the morbidity caused by such infections. This Review focuses on the interactions between enteric pathogens and human genetic determinants that alter intestinal function and inflammation and profoundly impair human health and development. We also discuss specific implications for novel approaches to interventions that are now opened by our rapidly growing molecular understanding.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.