ArticleMedscape journal of medicine2008
Study of plasma adrenomedullin level in normal pregnancy and preclampsia.
Article in Medscape journal of medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- High Serum Adrenomedullin and Mid-Regional Pro-Atrial Natriuretic Peptide Concentrations in Early Pregnancy Predict the Development of Gestational Hypertension.Diagnostics (Basel, Switzerland) · 2024Article
- Higher adrenomedullin levels during implantation are associated with successful pregnancy.Future science OA · 2020Article
- Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting.Journal of experimental & clinical cancer research : CR · 2018Review
- Clinical Presentation of Preeclampsia and the Diagnostic Value of Proteins and Their Methylation Products as Biomarkers in Pregnant Women with Preeclampsia and Their Newborns.Journal of pregnancy · 2018Review
- Shared biomarkers between female diastolic heart failure and pre-eclampsia: a systematic review and meta-analysis.ESC heart failure · 2017Review
- Adrenomedullin2 (ADM2)/Intermedin (IMD): A Potential Role in the Pathophysiology of Preeclampsia.The Journal of clinical endocrinology and metabolism · 2016Article
- Pancreatic Cancer-Derived Exosomes Cause Paraneoplastic β-cell Dysfunction.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Article
- The vitamin E-binding protein afamin increases in maternal serum during pregnancy.Clinica chimica acta; international journal of clinical chemistry · 2014Article
- Adrenomedullin signaling pathway polymorphisms and adverse pregnancy outcomes.American journal of perinatology · 2014Article
- Cigarette smoke-induced placental adrenomedullin expression and trophoblast cell invasion.Reproductive sciences (Thousand Oaks, Calif.) · 2014Article
- Adrenomedullin and pregnancy: perspectives from animal models to humans.Trends in endocrinology and metabolism: TEM · 2012Review
- Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models.Current hypertension reviews · 2011Article
- Molecular and vascular targets in the pathogenesis and management of the hypertension associated with preeclampsia.Cardiovascular & hematological agents in medicinal chemistry · 2010Article
- Potential markers of preeclampsia--a review.Reproductive biology and endocrinology : RB&E · 2009Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe aim of this study was to evaluate whether maternal circulating adrenomedullin (AM) values in patients with preeclampsia are different from those in normotensive pregnant women at different gestational ages. SUBJECTS AND
methodsIn a prospective clinical study, 90 women aged 17 to 40 years old, were divided into 4 main groups: group I (45 women): Normotensive pregnant women at first trimester (15 women), second trimester (15 women), and third trimester (15 women) of pregnancies. Group II (15 women): Pregnant women with preeclampsia at 25 to 38 weeks of gestation. Group III (15 women): Normotensive healthy nonpregnant women. Group IV (15 women): Hypertensive nonpregnant women. The plasma AM concentration was measured in all women by using enzyme immunoassay kits.
resultsPlasma AM levels in pregnant women with normal blood pressure at different gestational ages (first, second, and third trimesters) were statistically significantly higher than those detected in nonpregnant normotensive women and significantly increased with increasing gestational age (P < .001). Moreover, there was significant positive correlation between plasma AM levels and increasing gestational age (r = 0.915, P < .001). Preeclamptic patients had the highest mean plasma AM levels compared with all other groups, which is statistically significant (P < .001) and there was a significant positive correlation between plasma AM levels and systolic blood pressure, diastolic blood pressure, severity of preeclampsia, and proteinuria in pregnant patients with preeclampsia.
conclusionMaternal plasma AM concentration increases throughout pregnancy and increases as gestational age progresses. AM production starts very early in gestation, suggesting that it may have an important role in human reproduction, from implantation to delivery. Maternal plasma AM level in preeclampsia appears to be higher than that in normal pregnancy.
Indexed as
Identifiers
18382699PMC2270870W27820744What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.