Trial reportPloS one2008
Association of mild anemia with cognitive, functional, mood and quality of life outcomes in the elderly: the "Health and Anemia" study.
Trial report in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03907553 (Aging of Hematopoietic Stem Cells - Molecular Architecture of Marrow Dysplasia and Clinical Contribution of Ineffective Hematopoiesis to Frailty in the Elderly), which is not on this map. Cited by 63 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Aging of Hematopoietic Stem Cells - Molecular Architecture of Marrow Dysplasia and Clinical Contribution of Ineffective Hematopoiesis to Frailty in the Elderly
Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Chronic Cerebral Hypoxia and Cognitive Impairment: A Systematic Review and Meta-Analysis Based on Chronic Mountain Sickness, Anemia, Chronic Obstructive Pulmonary Disease, and Obstructive Sleep Apnea.CNS neuroscience & therapeutics · 2026Pooled it
- The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis.Nutrition journal · 2010Pooled it
- A randomised single-blind study to improve health-related quality of life by treating anaemia of chronic kidney disease with Aranesp® (darbepoetin alfa) in older people: STIMULATE.International urology and nephrology · 2014Trial
- Negative association of hemoglobin levels with mortality in older Japanese patients with dysphagia: a retrospective cohort study.Frontiers in medicine · 2026Article
- Article
- Anemia in patients ten years after bariatric surgery.International journal of obesity (2005) · 2025Article
- Preoperative anemia in older individuals undergoing major abdominal surgery is associated with early postoperative morbidity: a prospective observational study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024Observational
- Association between anemia and depression: results from NHANES 2005-2018 and mendelian randomization analyses.Annals of hematology · 2023Article
- Association of lifestyle behaviors with health-related quality of life among patients with hematologic diseases.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Association between Anemia Severity and Ischemic Stroke Incidence: A Retrospective Cohort Study.International journal of environmental research and public health · 2023Article
- Association of Anemia with Cognitive Function and Dementia Among Older Adults: The Role of Inflammation.Journal of Alzheimer's disease : JAD · 2023Article
- "Severe Anemia: A Case Report of an Uncommon Precipitant of Schizophrenia Relapse".Journal of blood medicine · 2023Article
- CERAD (Consortium to Establish a Registry for Alzheimer's Disease) Neuropsychology Assessment Battery: 35 Years and Counting.Journal of Alzheimer's disease : JAD · 2023Review
- Evaluating anemia on non-contrast thoracic computed tomography.Scientific reports · 2022Article
- Unexplained anemia of aging: Etiology, health consequences, and diagnostic criteria.Journal of the American Geriatrics Society · 2022Review
- Article
- Hematopoiesis, Inflammation and Aging-The Biological Background and Clinical Impact of Anemia and Increased C-Reactive Protein Levels on Elderly Individuals.Journal of clinical medicine · 2022Review
- Predict Postoperative Anemia of Patients: Nomogram Construction and Validation.Frontiers in surgery · 2022Article
- The Interplay between Anticholinergic Burden and Anemia in Relation to 1-Year Mortality among Older Patients Discharged from Acute Care Hospitals.Journal of clinical medicine · 2021Article
- Associations Between Anemia, Cognitive Impairment, and All-Cause Mortality in Oldest-Old Adults: A Prospective Population-Based Cohort Study.Frontiers in medicine · 2021Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the elderly persons, hemoglobin concentrations slightly below the lower limit of normal are common, but scant evidence is available on their relationship with significant health indicators. The objective of the present study was to cross-sectionally investigate the association of mild grade anemia with cognitive, functional, mood, and quality of life (QoL) variables in community-dwelling elderly persons.
methodsAmong the 4,068 eligible individuals aged 65-84 years, all persons with mild anemia (n = 170) and a randomly selected sample of non-anemic controls (n = 547) were included in the study. Anemia was defined according to World Health Organization (WHO) criteria and mild grade anemia was defined as a hemoglobin concentration between 10.0 and 11.9 g/dL in women and between 10.0 and 12.9 g/dL in men. Cognition and functional status were assessed using measures of selective attention, episodic memory, cognitive flexibility and instrumental and basic activities of daily living. Mood and QoL were evaluated by means of the Geriatric Depression Scale-10, the Short-Form health survey (SF-12), and the Functional Assessment of Cancer Therapy-Anemia.
resultsIn univariate analyses, mild anemic elderly persons had significantly worse results on almost all cognitive, functional, mood, and QoL measures. In multivariable logistic regressions, after adjustment for a large number of demographic and clinical confounders, mild anemia remained significantly associated with measures of selective attention and disease-specific QoL (all fully adjusted p<.046). When the lower limit of normal hemoglobin concentration according to WHO criteria was raised to define anemia (+0.2 g/dL), differences between mild anemic and non anemic elderly persons tended to increase on almost every variable.
conclusionsCross-sectionally, mild grade anemia was independently associated with worse selective attention performance and disease-specific QoL ratings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.