ReviewExperimental diabetes research2008
Intracellular signalling by C-peptide.
Review in Experimental diabetes research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 50 citations in OpenAlex.
- Magnesium from Deep Seawater as a Potentially Effective Natural Product against Insulin Resistance: A Randomized Trial.Medicina (Kaunas, Lithuania) · 2024Trial
- Unraveling C‑Peptide's Role in MIDY: A Structural Perspective.ACS omega · 2026Article
- Future clinical prospects of C-peptide testing in the early diagnosis of gestational diabetes.World journal of experimental medicine · 2024Review
- Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus.Fluids and barriers of the CNS · 2022Article
- C-peptide is a predictor of telomere shortening: A five-year longitudinal study.Frontiers in endocrinology · 2022Article
- Circulating obesity-driven biomarkers are associated with risk of clear cell renal cell carcinoma: a two-stage, case-control study.Carcinogenesis · 2019Article
- [C-peptide and cardiovascular mortality: systematic review and meta-analysisPéptido C y mortalidad cardiovascular: revisión sistemática y metanálisis].Revista panamericana de salud publica = Pan American journal of public health · 2019Review
- Association between low C-peptide and fragility fractures in postmenopausal women without diabetes.Journal of endocrinological investigation · 2017Article
- Plasma C-peptide, mammographic breast density, and risk of invasive breast cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Article
- The role of insulin C-peptide in the coevolution analyses of the insulin signaling pathway: a hint for its functions.PloS one · 2012Article
- C-peptide: a new mediator of atherosclerosis in diabetes.Mediators of inflammation · 2012Review
- C-peptide, a novel inhibitor of lung inflammation following hemorrhagic shock.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- C-peptide ameliorates kidney injury following hemorrhagic shock.Shock (Augusta, Ga.) · 2011Article
- Proinsulin C-peptide antagonizes the profibrotic effects of TGF-beta1 via up-regulation of retinoic acid and HGF-related signaling pathways.Molecular endocrinology (Baltimore, Md.) · 2010Article
- C-peptide is internalised in human endothelial and vascular smooth muscle cells via early endosomes.Diabetologia · 2009Article
- C-peptide of preproinsulin-like peptide 7: localization in the rat brain and activity in vitro.Neuroscience · 2009Article
- The beneficial effects of C-Peptide on diabetic polyneuropathy.The review of diabetic studies : RDS · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
C-peptide, a cleavage product of the proinsulin molecule, has long been regarded as biologically inert, serving merely as a surrogate marker for insulin release. Recent findings demonstrate both a physiological and protective role of C-peptide when administered to individuals with type I diabetes. Data indicate that C-peptide appears to bind in nanomolar concentrations to a cell surface receptor which is most likely to be G-protein coupled. Binding of C-peptide initiates multiple cellular effects, evoking a rise in intracellular calcium, increased PI-3-kinase activity, stimulation of the Na(+)/K(+) ATPase, increased eNOS transcription, and activation of the MAPK signalling pathway. These cell signalling effects have been studied in multiple cell types from multiple tissues. Overall these observations raise the possibility that C-peptide may serve as a potential therapeutic agent for the treatment or prevention of long-term complications associated with diabetes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.