ArticleHuman heredity2008
Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data.
Article in Human heredity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 282 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
282 citing papers in PubMed, 9 syntheses or guidelines pooled it, 610 citations in OpenAlex.
- An Intronic HCP5 Variant Is Associated With Age of Onset and Susceptibility to Graves Disease in UK and Polish Cohorts.The Journal of clinical endocrinology and metabolism · 2020Pooled it
- CTLA-4 as a genetic determinant in autoimmune Addison's disease.Genes and immunity · 2015Pooled it
- Association of HS6ST3 gene polymorphisms with obesity and triglycerides: gene x gender interaction.Journal of genetics · 2013Pooled it
- Genetic variants in the fat mass- and obesity-associated (FTO) gene are associated with alcohol dependence.Journal of molecular neuroscience : MN · 2013Pooled it
- A comprehensive family-based replication study of schizophrenia genes.JAMA psychiatry · 2013Pooled it
- Common variants in HLA-DRA gene are associated with alcohol dependence in two Caucasian samples.Journal of molecular neuroscience : MN · 2013Pooled it
- Common variants at 6p21.1 are associated with large artery atherosclerotic stroke.Nature genetics · 2012Pooled it
- GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia.Molecular psychiatry · 2011Pooled it
- No association of functional polymorphisms in methlylenetetrahydrofolate reductase and the risk and minor physical anomalies of schizophrenia in Korean population.Journal of Korean medical science · 2011Pooled it
- Genetic modulation of oxytocin sensitivity: a pharmacogenetic approach.Translational psychiatry · 2015Trial
- Replication Study of ENPP1 Variants and Haplotypes Associated with Severe Obesity in a Greek Adult Population.Biochemical genetics · 2026Article
- Indian ASD probands with 25(OH)D and vitamin D binding protein deficiency exhibited higher severity.Scientific reports · 2024Article
- Assessing the Occurrence and Influence of Cancer Chemotherapy-Related Pharmacogenetic Alleles in the Chilean Population.Pharmaceutics · 2024Article
- Metabotropic glutamate receptor genetic variants and peripheral receptor expression affects trait scores of autistic probands.Scientific reports · 2024Article
- Genetic Variations inJournal of obesity · 2024Article
- Glutamate receptor genetic variants affected peripheral glutamatergic transmission and treatment induced improvement of Indian ADHD probands.Scientific reports · 2023Article
- Analysis of neurotransmitters validates the importance of the dopaminergic system in autism spectrum disorder.World journal of pediatrics : WJP · 2023Article
- UBASH3A Interacts with PTPN22 to RegulateInternational journal of molecular sciences · 2023Article
- LRRTM3 Genetic Variations, rs1925575, and rs1925608 Contributed to Autism Spectrum Disorder Trait Severity: An Observation in The Indian Probands.International journal of molecular and cellular medicine · 2023Article
- A three-pronged analysis confirms the association of the serotoninergic system with attention deficit hyperactivity disorder.World journal of pediatrics : WJP · 2022Article
222 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Missing data occur in genetic association studies for several reasons including missing family members and uncertain haplotype phase. Maximum likelihood is a commonly used approach to accommodate missing data, but it can be difficult to apply to family-based association studies, because of possible loss of robustness to confounding by population stratification. Here a novel likelihood for nuclear families is proposed, in which distinct sets of association parameters are used to model the parental genotypes and the offspring genotypes. This approach is robust to population structure when the data are complete, and has only minor loss of robustness when there are missing data. It also allows a novel conditioning step that gives valid analysis for multiple offspring in the presence of linkage. Unrelated subjects are included by regarding them as the children of two missing parents. Simulations and theory indicate similar operating characteristics to TRANSMIT, but with no bias with missing data in the presence of linkage. In comparison with FBAT and PCPH, the proposed model is slightly less robust to population structure but has greater power to detect strong effects. In comparison to APL and MITDT, the model is more robust to stratification and can accommodate sibships of any size. The methods are implemented for binary and continuous traits in software, UNPHASED, available from the author.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.