Trial reportClinical cancer research : an official journal of the American Association for Cancer Research2008
Stress, immunity, and cervical cancer: biobehavioral outcomes of a randomized clinical trial [corrected].
Trial report in Clinical cancer research : an official journal of the American Association for Cancer Research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06048068 (Removing Surrogates' Uncertainty to Reduce Fear and Anxiety After Cardiac Events), which is not on this map. Cited by 45 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Removing Surrogates' Uncertainty to Reduce Fear and Anxiety After Cardiac Events (RESURFACE): A Randomized Pilot Intervention Study
Who cites it
45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- Rapid Systematic Review-Informed Multidisciplinary Expert Consensus on the Management of HPV-Positive Women with Low-Grade Cervical Lesions and the Role of aMedicina (Kaunas, Lithuania) · 2026Pooled it
- Salivary biomarkers for the prognosis of oncological and infectious diseases: a systematic review.Frontiers in dental medicine · 2025Pooled it
- Effectiveness of Stress-Reducing Interventions on the Response to Challenges to the Immune System: A Meta-Analytic Review.Psychotherapy and psychosomatics · 2019Pooled it
- The effect of technology-based interventions on pain, depression, and quality of life in patients with cancer: a systematic review of randomized controlled trials.Journal of medical Internet research · 2015Pooled it
- Trial
- Relationship between social support, quality of life, and Th2 cytokines in a biobehavioral cancer survivorship trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Trial
- A comparison of two psychological interventions for newly-diagnosed gynecological cancer patients.Gynecologic oncology · 2017Trial
- Psychosocial telephone counseling for survivors of cervical cancer: results of a randomized biobehavioral trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015Trial
- Longitudinal change in telomere length and the chronic stress response in a randomized pilot biobehavioral clinical study: implications for cancer prevention.Cancer prevention research (Philadelphia, Pa.) · 2012Trial
- Recruitment and retention results for a population-based cervical cancer biobehavioral clinical trial.Gynecologic oncology · 2011Trial
- Preservation of immune function in cervical cancer patients during chemoradiation using a novel integrative approach.Brain, behavior, and immunity · 2010Trial
- Can telephone counseling post-treatment improve psychosocial outcomes among early stage breast cancer survivors?Psycho-oncology · 2010Trial
- Trial
- Beyond survival: psychoneuroimmunology-driven cancer psychological rehabilitation-a paradigm shift from symptom management to biobehavioral remodeling.Frontiers in oncology · 2026Review
- The Interplay of Chronic Stress and Cancer: Pathophysiology and Implications for Integrated Care.Cancer reports (Hoboken, N.J.) · 2025Review
- Phase IIa Clinical Biomarker Trial of Dietary Arginine Restriction and Aspirin in Colorectal Cancer Patients.Cancers · 2023Article
- Effect of chronic stress on tumorigenesis and development.Cellular and molecular life sciences : CMLS · 2022Review
- Immunological and psychosocial functioning in parents of children with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- A systematic assessment of stress insomnia as the high-risk factor for cervical cancer and interplay of cervicovaginal microbiome.Frontiers in cellular and infection microbiology · 2022Review
- Psychosocial stress and immunosuppression in cancer: what can we learn from new research?BJPsych advances · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
purposeCancer diagnosis and treatment imparts chronic stressors affecting quality of life (QOL) and basic physiology. However, the capacity to increase survival by improving QOL is controversial. Patients with cervical cancer, in particular, have severely compromised QOL, providing a population well-suited for the evaluation of novel psychosocial interventions and the exploration of mechanisms by which modulation of the psychoneuroimmune axis might result in improved clinical outcomes. EXPERIMENTAL
designA randomized clinical trial was conducted in cervical cancer survivors that were enrolled at >or=13 and <22 months after diagnosis (n=50), comparing a unique psychosocial telephone counseling (PTC) intervention to usual care. QOL and biological specimens (saliva and blood) were collected at baseline and 4 months post-enrollment.
resultsThe PTC intervention yielded significantly improved QOL (P=0.011). Changes in QOL were significantly associated with a shift of immune system T helper type 1 and 2 (Th1/Th2) bias, as measured by IFN-gamma/interleukin-5 ELISpot T lymphocyte precursor frequency; improved QOL being associated with increased Th1 bias (P=0.012). Serum interleukin-10 and the neuroendocrine variables of cortisol and dehydroepiandrosterone revealed trends supporting this shift in immunologic stance and suggested a PTC-mediated decrease of the subject's chronic stress response.
conclusionsThis study documents the utility of a unique PTC intervention and an association between changes in QOL and adaptive immunity (T helper class). These data support the integration of the chronic stress response into biobehavioral models of cancer survivorship and suggests a novel mechanistic hypotheses by which interventions leading to enhanced QOL could result in improved clinical outcome including survival.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.