Evidence map›Paper›PMID 18381888›Full record

ReviewGenes & development2008

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin.

Thomas Dechat, Katrin Pfleghaar, Kaushik Sengupta, Takeshi Shimi, Dale K Shumaker, Liliana Solimando, Robert D Goldman

Open access · diamondAbstract readReview
In one paragraph

Review in Genes & development, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 564 papers.

0numbers the graph read from it
0cells of the map it votes in
564citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

564 citing papers in PubMed, 979 citations in OpenAlex.

  1. Review
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  11. From inflammation to inheritance: rethinking myocarditis as the first signal of desmosomal cardiomyopathy.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026
    Review
  12. Article
  13. Nuclear dysfunction in aging and neurodegeneration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

504 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Thomas DechatDepartment of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois 60611, USA.
Katrin Pfleghaar
Kaushik Sengupta
Takeshi Shimi
Dale K Shumaker
Liliana Solimando
Robert D Goldman
Northwestern University · US

Funding

INTERMEDIATE FILAMENTS IN NORMAL AND TRANSFORMED CELLSR01CA031760 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOLDMAN, ROBERT D · 1985 to 2013
$4.9M
LAMIN A PROGERIA MUTATIONS AND NUCLEAR FUNCTIONR01AG023776 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOLDMAN, ROBERT D · 2005 to 2010
$1.5M
NCI NIH HHS CA031760NCI NIH HHS R01 CA031760NIA NIH HHS AG023776NIA NIH HHS R01 AG023776
6 · The paper itself

Abstract

Over the past few years it has become evident that the intermediate filament proteins, the types A and B nuclear lamins, not only provide a structural framework for the nucleus, but are also essential for many aspects of normal nuclear function. Insights into lamin-related functions have been derived from studies of the remarkably large number of disease-causing mutations in the human lamin A gene. This review provides an up-to-date overview of the functions of nuclear lamins, emphasizing their roles in epigenetics, chromatin organization, DNA replication, transcription, and DNA repair. In addition, we discuss recent evidence supporting the importance of lamins in viral infections.

Indexed as

Amino Acid SequenceAnimalsCell NucleusChromatinHumansLaminsMicroscopy, ElectronMutationNuclear ProteinsProgeriaChromatinLaminsNuclear Proteins

Identifiers

PMID18381888
PMCPMC2732390
OpenAlexW2127394968

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.