ArticleStatistics in medicine2008
Generalizing from clinical trial data: a case study. The risk of suicidality among pediatric antidepressant users.
Article in Statistics in medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Reporting quality of studies using machine learning models for medical diagnosis: a systematic review.BMJ open · 2020Pooled it
- Meta-analysis of randomized trials on the association of prophylactic acyclovir and HIV-1 viral load in individuals coinfected with herpes simplex virus-2.AIDS (London, England) · 2011Pooled it
- Transporting the effect of the ASSIST school-based smoking prevention intervention to the Smoking, Drinking and Drug Use Among Young People in England Survey (2004-2021): A secondary analysis of a randomized controlled trial.Addiction (Abingdon, England) · 2025Trial
- Generalisability of an online randomised controlled trial: an empirical analysis.Journal of epidemiology and community health · 2018Trial
- Estimating the causal effect of randomization versus treatment preference in a doubly randomized preference trial.Psychological methods · 2012Trial
- Causal Inference With Survey Data: A Robust Framework for Propensity Score Weighting in Probability and Non-Probability Samples.Statistics in medicine · 2026Article
- Article
- Model-based standardization using multiple imputation.BMC medical research methodology · 2024Article
- Generalizability and Transportability of the National Lung Screening Trial Data: Extending Trial Results to Different Populations.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
- Target validity: Bringing treatment of external validity in line with internal validity.Current epidemiology reports · 2020Article
- The Epidemiologic Toolbox: Identifying, Honing, and Using the Right Tools for the Job.American journal of epidemiology · 2020Article
- Target Validity and the Hierarchy of Study Designs.American journal of epidemiology · 2019Article
- Projecting the Potential Effect of Using Paliperidone Palmitate Once-Monthly and Once-Every-3-Months Long-Acting Injections Among Medicaid Beneficiaries with Schizophrenia.Journal of managed care & specialty pharmacy · 2018Article
- The representativeness of eligible patients in type 2 diabetes trials: a case study using GIST 2.0.Journal of the American Medical Informatics Association : JAMIA · 2018Article
- Generalizing Study Results: A Potential Outcomes Perspective.Epidemiology (Cambridge, Mass.) · 2017Review
- Correlating eligibility criteria generalizability and adverse events using Big Data for patients and clinical trials.Annals of the New York Academy of Sciences · 2017Article
- Improving Depression Among HIV-Infected Adults: Transporting the Effect of a Depression Treatment Intervention to Routine Care.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- GIST 2.0: A scalable multi-trait metric for quantifying population representativeness of individual clinical studies.Journal of biomedical informatics · 2016Article
- Constrained Maximum Likelihood Estimation for Model Calibration Using Summary-level Information from External Big Data Sources.Journal of the American Statistical Association · 2016Article
- The effect of antiretroviral therapy on all-cause mortality, generalized to persons diagnosed with HIV in the USA, 2009-11.International journal of epidemiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
For the results of randomized controlled clinical trials (RCTs) and related meta-analyses to be useful in practice, they must be relevant to a definable group of patients in a particular clinical setting. To the extent this is so, we say that the trial is generalizable or externally valid. Although concern about the generalizability of the results of RCTs is often discussed, there are few examples of methods for assessing the generalizability of clinical trial data. In this paper, we describe and illustrate an approach for making what we call generalizability judgments and illustrate the approach in the context of a case study of the risk of suicidality among pediatric antidepressant users.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.