ArticleInflammatory bowel diseases2008
Bacteria and bacterial rRNA genes associated with the development of colitis in IL-10(-/-) mice.
Article in Inflammatory bowel diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- The effect of peanut skins as a natural antimicrobial feed additive on ileal and cecal microbiota in broiler chickens inoculated with Salmonella enterica Enteritidis.Poultry science · 2024Article
- Penthorum chinense Pursh improves type 2 diabetes mellitus via modulating gut microbiota in db/db mice.BMC complementary medicine and therapies · 2023Article
- [Diversity and functional prediction of gut microbiota in children with autism spectrum disorder].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Association of the Gut Microbiota With Cognitive Function in Midlife.JAMA network open · 2022Article
- Plasma levels of trimethylamine-N-oxide can be increased with 'healthy' and 'unhealthy' diets and do not correlate with the extent of atherosclerosis but with plaque instability.Cardiovascular research · 2021Article
- Food Additives, Gut Microbiota, and Irritable Bowel Syndrome: A Hidden Track.International journal of environmental research and public health · 2020Review
- High Levels of Oxidative Stress Create a Microenvironment That Significantly Decreases the Diversity of the Microbiota in Diabetic Chronic Wounds and Promotes Biofilm Formation.Frontiers in cellular and infection microbiology · 2020Article
- Regulatory effect of Garidisan on dysbiosis of the gut microbiota in the mouse model of ulcerative colitis induced by dextran sulfate sodium.BMC complementary and alternative medicine · 2019Article
- Colitis-induced colorectal cancer and intestinal epithelial estrogen receptor beta impact gut microbiota diversity.International journal of cancer · 2019Article
- Microbial network disturbances in relapsing refractory Crohn's disease.Nature medicine · 2019Article
- Article
- A Novel Prebiotic Blend Product Prevents Irritable Bowel Syndrome in Mice by Improving Gut Microbiota and Modulating Immune Response.Nutrients · 2017Article
- Gut dysbiosis in mice genetically selected for low antibody production.Gut pathogens · 2017Article
- Effect of exclusive enteral nutrition on the microbiota of children with newly diagnosed Crohn's disease.Clinical and translational gastroenterology · 2015Article
- Article
- PRISE2: software for designing sequence-selective PCR primers and probes.BMC bioinformatics · 2014Article
- Bioinformatic and immunological analysis reveals lack of support for measles virus related mimicry in Crohn's disease.BMC medicine · 2014Article
- Alteration of intestinal microbiota in mice orally administered with salmon cartilage proteoglycan, a prophylactic agent.PloS one · 2013Article
- Phylotype-level 16S rRNA analysis reveals new bacterial indicators of health state in acute murine colitis.The ISME journal · 2012Article
- Expression of the blood-group-related glycosyltransferase B4galnt2 influences the intestinal microbiota in mice.The ISME journal · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMicroorganisms appear to play important yet ill-defined roles in the etiology of inflammatory bowel disease (IBD). This study utilized a novel population-based approach to identify bacteria and bacterial rRNA genes associated with the development of colitis in IL-10(-/-) mice.
methodsMice were housed in 2 environments: a community mouse facility where the mice were fed nonsterile chow (Room 3) and a limited access facility where the mice were fed sterile chow (Room 4). Every month the disease activity levels were assessed and fecal bacterial compositions were analyzed. At the end of the experiments histological and bacterial analyses were performed on intestinal tissue.
resultsAlthough disease activity increased over time in both environments, it progressed at a faster rate in Room 3 than Room 4. Culture and culture-independent bacterial analyses identified several isolates and phylotypes associated with colitis. Two phylotypes (GpC2 and Gp66) were distinguished by their negative associations with disease activity in fecal and tissue samples. Notably, rRNA genes from these phylotypes had high sequence identity (99%) to an rRNA gene from a previously described flagellated Clostridium (Lachnospiraceae bacterium A4).
conclusionsThe negative associations of these 2 phylotypes (GpC2 and Gp66) suggest that these bacteria were being immunologically targeted, consistent with prior findings that the Lachnospiraceae bacterium A4 bears a prevalent flagellar antigen for disease-associated immunity in murine immune colitis and human Crohn's disease. Identification of these associations suggests that the experimental approach used in this study will have considerable utility in elucidating the host-microbe interactions underlying IBD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.