ArticleBMC developmental biology2008
Dominant negative Bmp5 mutation reveals key role of BMPs in skeletal response to mechanical stimulation.
Article in BMC developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Heterodimerization-dependent secretion of bone morphogenetic proteins in Drosophila.Developmental cell · 2023Article
- The Mandibular and Hyoid Arches-From Molecular Patterning to Shaping Bone and Cartilage.International journal of molecular sciences · 2021Review
- Whole-genome analyses identify loci and selective signals associated with body size in cattle.Journal of animal science · 2020Article
- A Multi-Omics Analysis of Bone Morphogenetic Protein 5 (Biomedicines · 2020Article
- Mutations in GDF11 and the extracellular antagonist, Follistatin, as a likely cause of Mendelian forms of orofacial clefting in humans.Human mutation · 2019Article
- BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis.eLife · 2019Article
- First Morphological and Molecular Evidence of the Negative Impact of Diatom-Derived Hydroxyacids on the Sea Urchin Paracentrotus lividus.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- The prodomain of BMP4 is necessary and sufficient to generate stable BMP4/7 heterodimers with enhanced bioactivity in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Tendon-to-bone attachment: from development to maturity.Birth defects research. Part C, Embryo today : reviews · 2014Review
- Dynamic compression of chondrocyte-agarose constructs reveals new candidate mechanosensitive genes.PloS one · 2012Article
- Dose-dependent differential effects of risedronate on gene expression in osteoblasts.Biochemical pharmacology · 2011Article
- How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging.Age (Dordrecht, Netherlands) · 2011Review
- Cell replication in craniofacial periosteum: appositional vs. resorptive sites.Journal of anatomy · 2011Article
- Review
- Article
- Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction.Developmental cell · 2009Article
- Osteoporosis: an evolutionary perspective.Human genetics · 2008Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundOver a hundred years ago, Wolff originally observed that bone growth and remodeling are exquisitely sensitive to mechanical forces acting on the skeleton. Clinical studies have noted that the size and the strength of bone increase with weight bearing and muscular activity and decrease with bed rest and disuse. Although the processes of mechanotransduction and functional response of bone to mechanical strain have been extensively studied, the molecular signaling mechanisms that mediate the response of bone cells to mechanical stimulation remain unclear.
resultsHere, we identify a novel germline mutation at the mouse Bone morphogenetic protein 5 (Bmp5) locus. Genetic analysis shows that the mutation occurs at a site encoding the proteolytic processing sequence of the BMP5 protein and blocks proper processing of BMP5. Anatomic studies reveal that this mutation affects the formation of multiple skeletal features including several muscle-induced skeletal sites in vivo. Biomechanical studies of osteoblasts from these anatomic sites show that the mutation inhibits the proper response of bone cells to mechanical stimulation.
conclusionThe results from these genetic, biochemical, and biomechanical studies suggest that BMPs are required not only for skeletal patterning during embryonic development, but also for bone response and remodeling to mechanical stimulation at specific anatomic sites in the skeleton.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.