ArticleThe European journal of neuroscience2008
ADAM2 promotes migration of neuroblasts in the rostral migratory stream to the olfactory bulb.
Article in The European journal of neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- CellBiAge: Improved single-cell age classification using data binarization.Cell reports · 2023Article
- Functions of 'A disintegrin and metalloproteases (ADAMs)' in the mammalian nervous system.Cellular and molecular life sciences : CMLS · 2019Review
- Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Physiological electrical signals promote chain migration of neuroblasts by up-regulating P2Y1 purinergic receptors and enhancing cell adhesion.Stem cell reviews and reports · 2015Article
- Evolution of Vertebrate Adam Genes; Duplication of Testicular Adams from Ancient Adam9/9-like Loci.PloS one · 2015Article
- Identification of radial glia-like cells in the adult mouse olfactory bulb.Experimental neurology · 2012Article
- Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development.Cellular & molecular biology letters · 2011Article
- Expression, immunolocalization and processing of fertilins ADAM-1 and ADAM-2 in the boar (Sus domesticus) spermatozoa during epididymal maturation.Reproductive biology and endocrinology : RB&E · 2011Article
- Girdin is an intrinsic regulator of neuroblast chain migration in the rostral migratory stream of the postnatal brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Endocannabinoids regulate the migration of subventricular zone-derived neuroblasts in the postnatal brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Control of neuronal migration through rostral migration stream in mice.Anatomy & cell biology · 2010Article
- ADAM function in embryogenesis.Seminars in cell & developmental biology · 2009Review
- The ADAM metalloproteinases.Molecular aspects of medicine · 2008Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
Neuroblasts migrate from the subventricular zone along the rostral migratory stream (RMS) to the olfactory bulb (OB). While the migration occurs by movement over other cells, the molecular mechanisms are poorly understood. We have found that ADAM2 (a disintegrin and metalloprotease 2) is expressed in migrating RMS neuroblasts and functions in their migration. The brains from ADAM2 knockout (KO) mice showed a smaller OB than that seen in wild-type (WT) mice at postnatal day 0. In addition, the RMS in ADAM2 KO mice appeared thinner and less voluminous in its rostral part and thicker in its caudal part. Estimates of migration in vivo using bromodeoxyuridine labeling revealed that neuroblasts from KO mice show a decreased migration rate compared with those from WT mice. Direct assays of migration by imaging living slices also showed a decreased migration speed and loss of directionality in the KO mice. This phenotype was similar to that seen in RMS containing slices from WT mice exposed to a peptide that mimicked the disintegrin loop of ADAM2. Finally, RMS explants from KO or WT mice that were cultured in Matrigel also revealed striking differences. The cells migrating out of explants from WT mice showed robust cell-cell interactions. In contrast, fewer cells migrated out of explants from ADAM2 KO mice, and those that did were largely dispersed and their migration inhibited. These experiments suggest that ADAM2 contributes to RMS migration, possibly through cell-cell interactions that mediate the rapid migration of the neuroblasts to their endpoint.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.