Evidence map›Paper›PMID 18380005›Full record

ReviewIUBMB life2008

Signaling mechanisms in skeletal muscle: acute responses and chronic adaptations to exercise.

Katja S C Röckl, Carol A Witczak, Laurie J Goodyear

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in IUBMB life, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 4 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 4 syntheses or guidelines pooled it, 219 citations in OpenAlex.

  1. Pooled it
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  5. Trial
  6. Intensive training and reduced volume increases muscle FXYD1 expression and phosphorylation at rest and during exercise in athletes.American journal of physiology. Regulatory, integrative and comparative physiology · 2016
    Trial
  7. Physical activity offsets the negative effects of a high-fructose diet.Medicine and science in sports and exercise · 2014
    Trial
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  15. Cancer Cachexia.Advances in experimental medicine and biology · 2025
    Review
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  19. Article
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Katja S C RöcklResearch Division, Joslin Diabetes Center and Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Carol A Witczak
Laurie J Goodyear
Harvard University · USJoslin Diabetes Center · US

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
EXERCISE REGULATION OF GLUCOSE UPTAKE IN SKELETAL MUSCLER01AR045670 · NIAMS · JOSLIN DIABETES CENTER · PI GOODYEAR, LAURIE J · 1998 to 2012
$4.6M
Regultion of Serine/Threonine Kinases in Skeletal MuscleR01DK068626 · NIDDK · JOSLIN DIABETES CENTER · PI GOODYEAR, LAURIE J · 2004 to 2012
$3.5M
Role of JNK1 in Skeletal Muscle Glucose MetabolismF32AR051663 · NIAMS · JOSLIN DIABETES CENTER · PI WITCZAK, CAROL · 2004 to 2006
$90k
NIAMS NIH HHS F32 AR051663NIAMS NIH HHS F32AR051663NIAMS NIH HHS R01 AR045670NIAMS NIH HHS R01AR45670NIDDK NIH HHS DK36836NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK068626NIDDK NIH HHS R01DK068626
6 · The paper itself

Abstract

Physical activity elicits physiological responses in skeletal muscle that result in a number of health benefits, in particular in disease states, such as type 2 diabetes. An acute bout of exercise/muscle contraction improves glucose homeostasis by increasing skeletal muscle glucose uptake, while chronic exercise training induces alterations in the expression of metabolic genes, such as those involved in muscle fiber type, mitochondrial biogenesis, or glucose transporter 4 (GLUT4) protein levels. A primary goal of exercise research is to elucidate the mechanisms that regulate these important metabolic and transcriptional events in skeletal muscle. In this review, we briefly summarize the current literature describing the molecular signals underlying skeletal muscle responses to acute and chronic exercise. The search for possible exercise/contraction-stimulated signaling proteins involved in glucose transport, muscle fiber type, and mitochondrial biogenesis is ongoing. Further research is needed because full elucidation of exercise-mediated signaling pathways would represent a significant step toward the development of new pharmacological targets for the treatment of metabolic diseases such as type 2 diabetes.

Indexed as

Adaptation, PhysiologicalExerciseAMP-Activated Protein KinasesCalcineurinCalcium-Calmodulin-Dependent Protein KinasesCyclic AMP-Dependent Protein KinasesGlucoseGTPase-Activating ProteinsHeat-Shock ProteinsHumansMultienzyme ComplexesMuscle, Skeletalp38 Mitogen-Activated Protein KinasesPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaProtein Kinase CProtein Serine-Threonine KinasesAMP-Activated Protein KinasesCalcineurinCalcium-Calmodulin-Dependent Protein KinasesCyclic AMP-Dependent Protein KinasesGlucoseGTPase-Activating ProteinsHeat-Shock ProteinsMultienzyme Complexesp38 Mitogen-Activated Protein KinasesPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPARGC1A protein, humanProtein Kinase CProtein Serine-Threonine KinasesTBC1D4 protein, humanTranscription Factors

Identifiers

PMID18380005
PMCPMC2885767
OpenAlexW2028964297

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.