ArticleJournal of human genetics2008
Variations in the FTO gene are associated with severe obesity in the Japanese.
Article in Journal of human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 11 of them syntheses that pooled it.
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Who cites it
101 citing papers in PubMed, 11 syntheses or guidelines pooled it, 244 citations in OpenAlex.
- Impact of fat mass and obesity-associated (FTO) gene variants on adult obesity and overweight: a comprehensive meta-analysis.BMC endocrine disorders · 2026Pooled it
- Comparison of the risk of obesity in the FTO rs9939609 genotype in a multiethnic group in Asia systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Single nucleotide polymorphisms (SNPs) that are associated with obesity and type 2 diabetes among Asians: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Association between fat mass and obesity-related variant and osteoarthritis risk: Integrated meta-analysis with bioinformatics.Frontiers in medicine · 2022Pooled it
- FTO gene polymorphisms and obesity risk in Chinese population: a meta-analysis.World journal of pediatrics : WJP · 2019Pooled it
- Japanese GWAS identifies variants for bust-size, dysmenorrhea, and menstrual fever that are eQTLs for relevant protein-coding or long non-coding RNAs.Scientific reports · 2018Pooled it
- Genetic variants in FTO associated with metabolic syndrome: a meta- and gene-based analysis.Molecular biology reports · 2012Pooled it
- Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians.Diabetologia · 2012Pooled it
- FTO gene polymorphisms and obesity risk: a meta-analysis.BMC medicine · 2011Pooled it
- An FTO variant is associated with Type 2 diabetes in South Asian populations after accounting for body mass index and waist circumference.Diabetic medicine : a journal of the British Diabetic Association · 2011Pooled it
- Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes.BMC medical genetics · 2009Pooled it
- A haplotype of three SNPs in FTO had a strong association with body composition and BMI in Iranian male adolescents.PloS one · 2018Trial
- Dietary Fat Modifies the Effects of FTO Genotype on Changes in Insulin Sensitivity.The Journal of nutrition · 2015Trial
- FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: the POUNDS LOST Trial.Diabetes · 2012Trial
- Associations between an obesity related genetic variant (FTO rs9939609) and prostate cancer risk.PloS one · 2010Trial
- Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program.Diabetologia · 2008Trial
- Unexpected identification of obesity-associated mutations in LEP and MC4R genes in patients with anorexia nervosa.Scientific reports · 2024Article
- Investigation of genetic markers associated to type 2 diabetes mellitus in Santarém-Pará.Genetics and molecular biology · 2024Article
- Differential Association of FTO Gene variants and Haplotypes with the Susceptibility to Polycystic Ovary Syndrome According To Obesity in Women with PCOS.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Minor alleles in theNutrition research and practice · 2023Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
27 authors at 15 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Variations in the fat-mass and obesity-associated gene (FTO) are associated with the obesity phenotype in many Caucasian populations. This association with the obesity phenotype is not clear in the Japanese. To investigate the relationship between the FTO gene and obesity in the Japanese, we genotyped single nucleotide polymorphisms (SNPs) in the FTO genes from severely obese subjects [n = 927, body mass index (BMI) > or = 30 kg/m2] and normal-weight control subjects (n = 1,527, BMI < 25 kg/m2). A case-control association analysis revealed that 15 SNPs, including rs9939609 and rs1121980, in a linkage disequilibrium (LD) block of approximately 50 kb demonstrated significant associations with obesity; rs1558902 was most significantly associated with obesity. P value in additive mode was 0.0000041, and odds ratio (OR) adjusted for age and gender was 1.41 [95% confidential interval (CI) = 1.22-1.62]. Obesity-associated phenotypes, which include the level of plasma glucose, hemoglobin A1c, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure were not associated with the rs1558902 genotype. Thus, the SNPs in the FTO gene were found to be associated with obesity, i.e., severe obesity, in the Japanese.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.