ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2008
Aging results in increased autophagy of mitochondria and protein nitration in rat hepatocytes following heat stress.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 64 citations in OpenAlex.
- Links Between Autophagy and Healthy Aging.Journal of molecular biology · 2026Review
- A holistic adaptive ageing framework (HAAF) to address complex challenges in ageing.Zeitschrift fur Gerontologie und Geriatrie · 2025Review
- Heat Stress-Mediated Multi-Organ Injury: Pathophysiology and Treatment Strategies.Comprehensive Physiology · 2025Review
- Altered accumulation of hepatic mitochondrial antioxidant proteins with age and environmental heat stress.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Hormetic Heat Shock Enhances Autophagy through HSF1 in Retinal Pigment Epithelium Cells.Cells · 2022Article
- Heat Treatment Improves Hepatic Mitochondrial Respiratory Efficiency via Mitochondrial Remodeling.Function (Oxford, England) · 2021Article
- Signs of ROS-Associated Autophagy in Testis and Sperm in a Rat Model of Varicocele.Oxidative medicine and cellular longevity · 2020Article
- A Futile Battle? Protein Quality Control and the Stress of Aging.Developmental cell · 2018Review
- The Effects of Kaempferol-Inhibited Autophagy on Osteoclast Formation.International journal of molecular sciences · 2018Article
- TRIENNIAL LACTATION SYMPOSIUM/BOLFA: Late gestation heat stress of dairy cattle programs dam and daughter milk production.Journal of animal science · 2017Review
- Heat stress causes dysfunctional autophagy in oxidative skeletal muscle.Physiological reports · 2017Article
- Fragmentation of the mitochondrial network in skin in vivo.PloS one · 2017Article
- Heat shock protein 70 and AMP-activated protein kinase contribute to 17-DMAG-dependent protection against heat stroke.Journal of cellular and molecular medicine · 2016Article
- Quality Saving Mechanisms of Mitochondria during Aging in a Fully Time-Dependent Computational Biophysical Model.PloS one · 2016Article
- Heat shock response and autophagy--cooperation and control.Autophagy · 2015Review
- Aging impairs induction of redox factor-1 after heat stress: a potential mechanism for heat-induced liver injury.International journal of physiology, pathophysiology and pharmacology · 2015Article
- The adaptor protein p62 is involved in RANKL-induced autophagy and osteoclastogenesis.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2014Article
- Deficient import of acetyl-CoA into the ER lumen causes neurodegeneration and propensity to infections, inflammation, and cancer.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Altered expression of iron regulatory proteins with aging is associated with transient hepatic iron accumulation after environmental heat stress.Blood cells, molecules & diseases · 2014Article
- Hyperammonemia-mediated autophagy in skeletal muscle contributes to sarcopenia of cirrhosis.American journal of physiology. Endocrinology and metabolism · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The natural breakdown of cells, tissues, and organ systems is a significant consequence of aging and is at least partially caused by a decreased ability to tolerate environmental stressors. Based on quantitative ultrastructural analysis using transmission electron microscopy and computer imaging, we show significant differences in hepatocyte morphology between young and old rats during a 48-hr recovery period following a 2-day heat stress protocol. Mitochondrial injury was greater overall in old compared with young rats. Autophagy was observed in both young and old rats, with autophagy greater overall in old compared with young hepatocytes. Lipid peroxidation and protein nitration were evaluated by localization and quantification of 4-hydroxy-2-nonenal (4-HNE)-modified protein adducts and 3-nitrotyrosine (3-NT) levels, respectively. Levels of 3-NT but not 4-HNE-protein adducts were significantly elevated in hepatocytes of old rats in comparison with young at 90 min after heat stress, suggesting a major role for reactive nitrogen species in the pathology observed at this time point. These results show a differential response of hepatocyte mitochondria to heat stress with aging, as well as greater levels of both autophagic and nitrative damage in old vs young hepatocytes. This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials.
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Registered trials
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