ArticleMolecular and cellular biology2008
Molecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 complex.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 46 citations in OpenAlex.
- A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- XPG-related nucleases are hierarchically recruited for double-stranded rDNA break resection.The Journal of biological chemistry · 2019Article
- Interdependent and separable functions ofProceedings of the National Academy of Sciences of the United States of America · 2018Article
- CtIP/Ctp1/Sae2, molecular form fit for function.DNA repair · 2017Review
- YM155 inhibits topoisomerase function.Anti-cancer drugs · 2017Article
- Ctp1-dependent clipping and resection of DNA double-strand breaks by Mre11 endonuclease complex are not genetically separable.Nucleic acids research · 2016Article
- DNA End Resection: Facts and Mechanisms.Genomics, proteomics & bioinformatics · 2016Review
- S. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex.Nucleic acids research · 2016Article
- Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors.Oncotarget · 2016Article
- Two separable functions of Ctp1 in the early steps of meiotic DNA double-strand break repair.Nucleic acids research · 2015Article
- Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair.Nature structural & molecular biology · 2015Article
- Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks.Nature · 2014Article
- Structural studies of DNA end detection and resection in homologous recombination.Cold Spring Harbor perspectives in biology · 2014Review
- Activation of DSB processing requires phosphorylation of CtIP by ATR.Molecular cell · 2013Article
- The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair.PLoS genetics · 2013Article
- Regulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.PLoS genetics · 2011Article
- Activation of protein kinase Tel1 through recognition of protein-bound DNA ends.Molecular and cellular biology · 2011Article
- The MRE11 complex: starting from the ends.Nature reviews. Molecular cell biology · 2011Review
- DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints.Trends in cell biology · 2010Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Schizosaccharomyces pombe nip1(+)/ctp1(+) gene was previously identified as an slr (synthetically lethal with rad2) mutant. Epistasis analysis indicated that Nip1/Ctp1 functions in Rhp51-dependent recombinational repair, together with the Rad32 (spMre11)-Rad50-Nbs1 complex, which plays important roles in the early steps of DNA double-strand break repair. Nip1/Ctp1 was phosphorylated in asynchronous, exponentially growing cells and further phosphorylated in response to bleomycin treatment. Overproduction of Nip1/Ctp1 suppressed the DNA repair defect of an nbs1-s10 mutant, which carries a mutation in the FHA phosphopeptide-binding domain of Nbs1, but not of an nbs1 null mutant. Meiotic DNA double-strand breaks accumulated in the nip1/ctp1 mutant. The DNA repair phenotypes and epistasis relationships of nip1/ctp1 are very similar to those of the Saccharomyces cerevisiae sae2/com1 mutant, suggesting that Nip1/Ctp1 is a functional homologue of Sae2/Com1, although the sequence similarity between the proteins is limited to the C-terminal region containing the RHR motif. We found that the RxxL and CxxC motifs are conserved in Schizosaccharomyces species and in vertebrate CtIP, originally identified as a cofactor of the transcriptional corepressor CtBP. However, these two motifs are not found in other fungi, including Saccharomyces and Aspergillus species. We propose that Nip1/Ctp1 is a functional counterpart of Sae2/Com1 and CtIP.
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