ArticleNeurobiology of learning and memory2008
Nicotinic modulation of tone-evoked responses in auditory cortex reflects the strength of prior auditory learning.
Article in Neurobiology of learning and memory, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Chronic nicotine reverses age-related decline of interneuron markers in mouse auditory cortex.Frontiers in aging neuroscience · 2026Article
- Sequence-specific delayed gains in motor fluency evolve after movement observation training in the absence of early sleep.Scientific reports · 2024Article
- Cholinergic modulation in the vertebrate auditory pathway.Frontiers in cellular neuroscience · 2024Review
- Alpha-2 nicotinic acetylcholine receptors regulate spectral integration in auditory cortex.Frontiers in neural circuits · 2024Article
- Cholinergic modulation of sensory perception and plasticity.Neuroscience and biobehavioral reviews · 2023Review
- Nicotinic Receptor Subunit Distribution in Auditory Cortex: Impact of Aging on Receptor Number and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Acute administration of nicotine into the higher order auditory Te2 cortex specifically decreases the fear-related charge of remote emotional memories.Neuropharmacology · 2015Article
- Cholinergic Modulation of Stimulus-Specific Adaptation in the Inferior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Molecules and circuits involved in nicotine addiction: The many faces of smoking.Neuropharmacology · 2014Review
- Convergence of nicotine-induced and auditory-evoked neural activity activates ERK in auditory cortex.Synapse (New York, N.Y.) · 2013Article
- Cortical cholinergic input is required for normal auditory perception and experience-dependent plasticity in adult ferrets.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Tone-detection training enhances spectral integration mediated by intracortical pathways in primary auditory cortex.Neurobiology of learning and memory · 2013Article
- Pre-attentive, context-specific representation of fear memory in the auditory cortex of rat.PloS one · 2013Article
- Nicotinic neuromodulation in auditory cortex requires MAPK activation in thalamocortical and intracortical circuits.Journal of neurophysiology · 2012Article
- Nicotinic acetylcholine receptors in rat forebrain that bind ¹⁸F-nifene: relating PET imaging, autoradiography, and behavior.Synapse (New York, N.Y.) · 2012Article
- Nicotinic filtering of sensory processing in auditory cortex.Frontiers in behavioral neuroscience · 2012Article
- Nicotine, Auditory Sensory Memory, and sustained Attention in a Human Ketamine Model of Schizophrenia: Moderating Influence of a Hallucinatory Trait.Frontiers in pharmacology · 2012Article
- M1 muscarinic receptor for the development of auditory cortical function.Molecular brain · 2010Review
- Young and older good learners have higher levels of brain nicotinic receptor binding.Neurobiology of aging · 2010Article
- Stability of thalamocortical synaptic transmission across awake brain states.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Nicotinic acetylcholine receptors (nAChRs) contribute to sensory-cognitive function, as demonstrated by evidence that nAChR activation enhances, and nAChR blockade impairs, neural processing of sensory stimuli and sensory-cognitive behavior. To better understand the relationship between nAChR function and behavior, here we compare the strength of nAChR-mediated physiology in individual animals to their prior auditory behavioral performance. Adult rats were trained on an auditory-cued, active avoidance task over 4 days and classified as "good," "intermediate" or "poor" performers based on their initial rate of learning and eventual level of performance. Animals were then anesthetized, and tone-evoked local field potentials (LFPs) recorded in layer 4 of auditory cortex (ACx) before and after a test dose of nicotine (0.7mg/kg, s.c.) or saline. In "good" performers, nicotine enhanced LFP amplitude and decreased response threshold to characteristic frequency (CF) stimuli, yet had opposite effects (decreased amplitude, increased threshold) on responses to spectrally distant stimuli; i.e., cortical receptive fields became more selective for CF stimuli. In contrast, nicotine had little effect on LFP amplitude in "intermediate" or "poor" performing animals. Nicotine did, however, reduce LFP onset latency in all three groups, indicating that all received an effective dose of the drug. Our findings suggest that nicotinic regulation of cortical receptive fields may be a distinguishing feature of the best-performing animals, and may facilitate sensory-related learning by enhancing receptive field selectivity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.