ArticleNeurobiology of aging2009
DNA base excision repair activities in mouse models of Alzheimer's disease.
Article in Neurobiology of aging, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Shared molecular mechanisms in aging and neurodegenerative diseases: from mechanistic insights to therapeutic strategies.Frontiers in human neuroscience · 2026Review
- How do neurons live long and healthy? The mechanism of neuronal genome integrity.Frontiers in neuroscience · 2025Review
- Loss of DNA glycosylases improves health and cognitive function in a C. elegans model of human tauopathy.Nucleic acids research · 2024Article
- Review
- DNA Damage-Induced Neurodegeneration in Accelerated Ageing and Alzheimer's Disease.International journal of molecular sciences · 2021Review
- Genome instability in Alzheimer disease.Mechanisms of ageing and development · 2017Review
- Activation of GLP-1 Receptor Enhances Neuronal Base Excision Repair via PI3K-AKT-Induced Expression of Apurinic/Apyrimidinic Endonuclease 1.Theranostics · 2016Article
- Genomic integrity and the ageing brain.Nature reviews. Neuroscience · 2015Review
- The case for rejecting the amyloid cascade hypothesis.Nature neuroscience · 2015Review
- BDNF and exercise enhance neuronal DNA repair by stimulating CREB-mediated production of apurinic/apyrimidinic endonuclease 1.Neuromolecular medicine · 2014Article
- The role of DNA repair in brain related disease pathology.DNA repair · 2013Review
- Modulation of DNA base excision repair during neuronal differentiation.Neurobiology of aging · 2013Article
- Alzheimer's disease-associated neurotoxic peptide amyloid-β impairs base excision repair in human neuroblastoma cells.International journal of molecular sciences · 2012Article
- Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer's disease.Neurobiology of aging · 2012Article
- Balancing repair and tolerance of DNA damage caused by alkylating agents.Nature reviews. Cancer · 2012Review
- Nuclear and mitochondrial DNA repair in selected eukaryotic aging model systems.Oxidative medicine and cellular longevity · 2012Review
- DNA repair deficiency in neurodegeneration.Progress in neurobiology · 2011Review
- Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Alzheimer's disease (AD) has been correlated with elevated levels of oxidative DNA damage. Base excision repair (BER) is the main repair pathway for the removal of oxidative DNA base modifications. We have recently found significant functional deficiencies in BER in brains of sporadic AD and amnestic mild cognitive impairment patients. In this study we tested whether altered BER activities are associated with appearance of symptoms in different brain regions of pre-symptomatic and symptomatic mice harboring mutant APP alone or in combination with Tau and PS1. Our results suggest that unlike in humans, the development of AD-like pathology in the studied mouse models is not associated with deficiencies in BER.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.