ArticleBrain research2008
Changes in osmolality modulate voltage-gated calcium channels in trigeminal ganglion neurons.
Article in Brain research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Involvement of the Transient Receptor Channels in Preclinical Models of Musculoskeletal Pain.Current neuropharmacology · 2024Review
- Article
- TRPV4 plays an important role in rat prefrontal cortex changes induced by acute hypoxic exercise.Saudi journal of biological sciences · 2019Article
- The Role of Transient Receptor Potential (TRP) Channels in the Transduction of Dental Pain.International journal of molecular sciences · 2019Review
- Regulation of Pain and Itch by TRP Channels.Neuroscience bulletin · 2018Review
- Transient Receptor Potential Vanilloid 4-Induced Modulation of Voltage-Gated Sodium Channels in Hippocampal Neurons.Molecular neurobiology · 2016Article
- Transient Receptor Potential Vanilloid 4 Inhibits γ-Aminobutyric Acid-Activated Current in Hippocampal Pyramidal Neurons.Frontiers in molecular neuroscience · 2016Article
- Targeting TRP channels for novel migraine therapeutics.ACS chemical neuroscience · 2014Review
- Transient receptor potential vanilloid 4 mediates hypotonicity-induced enhancement of synaptic transmission in hippocampal slices.CNS neuroscience & therapeutics · 2013Article
- Activation of Transient Receptor Potential Vanilloid 4 Increases NMDA-Activated Current in Hippocampal Pyramidal Neurons.Frontiers in cellular neuroscience · 2013Article
- Activation of TRPV4 on dural afferents produces headache-related behavior in a preclinical rat model.Cephalalgia : an international journal of headache · 2011Article
- Hypotonicity modulates tetrodotoxin-sensitive sodium current in trigeminal ganglion neurons.Molecular pain · 2011Article
- Hyposmotic challenge modulates function of L-type calcium channel in rat ventricular myocytes through protein kinase C.Acta pharmacologica Sinica · 2010Article
- International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family.Pharmacological reviews · 2010Review
- Osmolality-induced tuning of action potentials in trigeminal ganglion neurons.Neuroscience letters · 2009Article
- Altered central TRPV4 expression and lipid raft association related to inappropriate vasopressin secretion in cirrhotic rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Voltage-gated calcium channels (VGCCs) participate in many important physiological functions. However whether VGCCs are modulated by changes of osmolarity and involved in anisotonicity-induced nociception is still unknown. For this reason by using whole-cell patch clamp techniques in rat and mouse trigeminal ganglion (TG) neurons we tested the effects of hypo- and hypertonicity on VGCCs. We found that high-voltage-gated calcium current (I(HVA)) was inhibited by both hypo- and hypertonicity. In rat TG neurons, the inhibition by hypotonicity was mimicked by Transient Receptor Potential Vanilloid 4 receptor (TRPV4) activator but hypotonicity did not exhibit inhibition in TRPV4(-/-) mice TG neurons. Concerning the downstream signaling pathways, antagonism of PKG pathway selectively reduced the hypotonicity-induced inhibition, whereas inhibition of PLC- and PI3K-mediated pathways selectively reduced the inhibition produced by hypertonicity. In summary, although the effects of hypo- and hypertonicity show similar phenotype, receptor and intracellular signaling pathways were selective for hypo- versus hypertonicity-induced inhibition of I(HVA).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.