ArticleBiomaterials2008
Bioadhesive hydrogel microenvironments to modulate epithelial morphogenesis.
Article in Biomaterials, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 75 citations in OpenAlex.
- A human in vitro model that mimics the renal proximal tubule.Tissue engineering. Part C, Methods · 2014Trial
- Cell Contractile Force-Mediated Morphogenetic Tissue Engineering via 4D Printed Degradable Hydrogel Scaffolds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- 3D Hydrogel Encapsulation Regulates Nephrogenesis in Kidney Organoids.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Advancements and Challenges in Hydrogel Engineering for Regenerative Medicine.Gels (Basel, Switzerland) · 2024Review
- Matrix Degradability Contributes to the Development of Salivary Gland Progenitor Cells with Secretory Functions.ACS applied materials & interfaces · 2023Article
- Exploiting Meltable Protein Hydrogels to Encapsulate and Culture Cells in 3D.Macromolecular bioscience · 2022Article
- Synthetic Collagen-like Polymer That Undergoes a Sol-Gel Transition Triggered byInternational journal of molecular sciences · 2022Article
- Role of extracellular matrix components and structure in new renal modelsFrontiers in physiology · 2022Review
- Article
- Organoids as a new model system to study neural tube defects.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Review
- Article
- A biodegradable soy protein isolate-based waterborne polyurethane composite sponge for implantable tissue engineering.Journal of materials science. Materials in medicine · 2020Article
- Effect of incorporating clustered silica nanoparticles on the performance and biocompatibility of catechol-containing PEG-based bioadhesive.Biomedical materials (Bristol, England) · 2018Article
- Fundamentals of Laser-Based Hydrogel Degradation and Applications in Cell and Tissue Engineering.Advanced healthcare materials · 2017Review
- Engineering 3D Models of Tumors and Bone to Understand Tumor-Induced Bone Disease and Improve Treatments.Current osteoporosis reports · 2017Review
- Tuning Hydrogel Properties to Promote the Assembly of Salivary Gland Spheroids in 3D.ACS biomaterials science & engineering · 2016Article
- Neural tube morphogenesis in synthetic 3D microenvironments.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Gelatin Microgel Incorporated Poly(ethylene glycol)-Based Bioadhesive with Enhanced Adhesive Property and Bioactivity.ACS applied materials & interfaces · 2016Article
- Evolving insights in cell-matrix interactions: elucidating how non-soluble properties of the extracellular niche direct stem cell fate.Acta biomaterialia · 2015Review
- Hydrogels and scaffolds for immunomodulation.Advanced materials (Deerfield Beach, Fla.) · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Epithelial cells polarize and differentiate into organotypic cell aggregates in response to cell-cell and cell-matrix interactions. For example, Madin-Darby Canine Kidney (MDCK) cells form spherical cell aggregates (cysts) with distinct apical and basolateral polarity when cultured three dimensionally (embedded) in type I collagen gels. To investigate the effects of individual extracellular factors on epithelial morphogenesis, we engineered fast degrading protease-responsive polyethylene glycol (PEG) hydrogels functionalized with controlled densities of various bioligands (RGD peptide, laminin-1 (LN)) to allow 3D culturing of MDCK cells, cyst expansion, and morphogenesis/polarization. Cysts formed after 15 days of culture in these hydrogels were analyzed with multiphoton fluorescence microscopy for markers of apical and basolateral membrane domains. Epithelial cysts formed in bioadhesive ligand-functionalized PEG gels exhibited a higher frequency of central lumen and interior apical pole formation as well as basolateral polarization compared to those of unmodified PEG hydrogels. These results demonstrate that incorporation of specific bioadhesive motifs into synthetic hydrogels provides 3D culture environments that support epithelial morphogenesis. These microenvironments provide a flexible and controlled system for systematic investigations into normal and pathologic morphogenic behaviours as well as synthetic environments for promoting tissue morphogenesis for regenerative medicine applications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.