ArticleCurrent infectious disease reports2008
Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort?
Article in Current infectious disease reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- A clash of quorum sensing vs quorum sensing inhibitors: an overview and risk of resistance.Archives of microbiology · 2023Review
- Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023Review
- Anti-quorum sensing and biofilm inhibitory effect of some medicinal plants against gram-negative bacterial pathogens:Heliyon · 2022Article
- Damage-free light-induced assembly of intestinal bacteria with a bubble-mimetic substrate.Communications biology · 2021Article
- Naringenin Inhibition of theFrontiers in molecular biosciences · 2020Article
- Understanding Biofilms and Novel Approaches to the Diagnosis, Prevention, and Treatment of Medical Device-Associated Infections.Infectious disease clinics of North America · 2018Review
- Biogenic synthesis of silver nanoparticles using Piper betle aqueous extract and evaluation of its anti-quorum sensing and antibiofilm potential against uropathogens with cytotoxic effects: an in vitro and in vivo approach.Environmental science and pollution research international · 2018Article
- Seed Extract ofFrontiers in cellular and infection microbiology · 2018Article
- Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes.International journal of molecular sciences · 2017Review
- Article
- Plausible Drug Targets in the Streptococcus mutans Quorum Sensing Pathways to Combat Dental Biofilms and Associated Risks.Indian journal of microbiology · 2015Review
- Antibiotic discovery: combatting bacterial resistance in cells and in biofilm communities.Molecules (Basel, Switzerland) · 2015Review
- Evolution of resistance to quorum-sensing inhibitors.Microbial ecology · 2014Review
- Rhodotorula mucilaginosa, a quorum quenching yeast exhibiting lactonase activity isolated from a tropical shoreline.Sensors (Basel, Switzerland) · 2014Article
- Antibiotic alternatives: the substitution of antibiotics in animal husbandry?Frontiers in microbiology · 2014Review
- Quorum quenching mediated approaches for control of membrane biofouling.International journal of biological sciences · 2014Review
- Screening of Actinobacillus pleuropneumoniae LuxS inhibitors.Current microbiology · 2013Article
- Applying insights from biofilm biology to drug development - can a new approach be developed?Nature reviews. Drug discovery · 2013Review
- Doxycycline interferes with quorum sensing-mediated virulence factors and biofilm formation in gram-negative bacteria.World journal of microbiology & biotechnology · 2013Article
- Enhancing the utility of existing antibiotics by targeting bacterial behaviour?British journal of pharmacology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial resistance poses a major challenge to the development of new antimicrobial agents. Conventional antibiotics have an inherent obsolescence because they select for development of resistance. Bacterial infections have again become a serious threat in developed countries. Particularly, elderly, immunocompromised, and hospitalized patients are susceptible to infections caused by bacteria such as Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis. These bacteria form chronic, biofilm-based infections, which are challenging because bacterial cells living as biofilms are more tolerant to antibiotics than their planktonic counterparts. Therefore, research should identify new antimicrobial agents and their corresponding targets to decrease the biofilm-forming capability or persistence of the infectious bacteria. Here, we review one such drug target: bacterial cell-to-cell communication systems, or quorum sensing.
Identifiers
18377811What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.