ReviewCurrent gastroenterology reports2007
Microbial host interactions in IBD: implications for pathogenesis and therapy.
Review in Current gastroenterology reports, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02516384 (Fecal Microbiota Transplantation), which is not on this map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fecal Microbiota Transplantation (FMT) in the Management of Ulcerative Colitis (UC)
Who cites it
45 citing papers in PubMed, 103 citations in OpenAlex.
- Comprehensive Multi-Omic Evaluation of the Microbiota and Metabolites in the Colons of Diverse Swine Breeds.Animals : an open access journal from MDPI · 2024Article
- Priority order of neonatal colonization by a probiotic or pathogenicFrontiers in microbiology · 2024Article
- Capecitabine-associated gastrointestinal ulceration, haemorrhage, and obstruction: a pharmacovigilance analysis based on the FAERS.Frontiers in pharmacology · 2024Article
- Review
- Article
- HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice.Frontiers in immunology · 2021Article
- New Studies of Pathogenesis of Rheumatoid Arthritis with Collagen-Induced and Collagen Antibody-Induced Arthritis Models: New Insight Involving Bacteria Flora.Autoimmune diseases · 2021Review
- Serum adropin levels are reduced in patients with inflammatory bowel diseases.Scientific reports · 2020Article
- Changes in the Intestinal Microbiota Are Seen Following Treatment with Infliximab in Children with Crohn's Disease.Journal of clinical medicine · 2020Article
- Review
- Association between variants of the autophagy related gene ATG16L1 in inflammatory bowel diseases and clinical statues.Gastroenterology and hepatology from bed to bench · 2019Article
- Diet and microbiota in inflammatory bowel disease: The gut in disharmony.World journal of gastroenterology · 2017Review
- Helicobacter bilis Infection Alters Mucosal Bacteria and Modulates Colitis Development in Defined Microbiota Mice.Inflammatory bowel diseases · 2016Article
- Modulation of microbiota as treatment for intestinal inflammatory disorders: An uptodate.World journal of gastroenterology · 2016Review
- Death in the intestinal epithelium-basic biology and implications for inflammatory bowel disease.The FEBS journal · 2016Review
- Alterations of the Ileal and Colonic Mucosal Microbiota in Canine Chronic Enteropathies.PloS one · 2016Article
- Crohn's disease: a clinical update.Therapeutic advances in gastroenterology · 2015Review
- TGF-β converts Th1 cells into Th17 cells through stimulation of Runx1 expression.European journal of immunology · 2015Article
- Genetic deletion of Klf4 in the mouse intestinal epithelium ameliorates dextran sodium sulfate-induced colitis by modulating the NF-κB pathway inflammatory response.Inflammatory bowel diseases · 2014Article
- Live Combined Bacillus subtilis and Enterococcus faecium Ameliorate Murine Experimental Colitis by Immunosuppression.International journal of inflammation · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Crohn's disease (CD), ulcerative colitis (UC), and pouchitis appear to be caused by pathogenic T-cell responses to discrete antigens from the complex luminal microbiota, with susceptibility conferred by genetic polymorphisms that regulate bacterial killing, mucosal barrier function, or immune responses. Environmental triggers initiate or reactivate inflammation and modulate genetic susceptibility. New pathogenesis concepts include defective bacterial killing by innate immune cells in CD, colonization of the ileum in CD with functionally abnormal Escherichia coli that adhere to and invade epithelial cells and resist bacterial killing, and alterations in enteric microbiota composition in CD, UC, and pouchitis detected by molecular probes. The considerable therapeutic potential of manipulating the enteric microbiota in inflammatory bowel disease patients has not been realized, probably due to failure to recognize heterogenic disease mechanisms that require individualized use of antibiotics, probiotics, prebiotics, combination therapies, and genetically engineered bacteria to restore mucosal homeostasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.