ArticleGenome biology2008
Reduced reliance on the trace element selenium during evolution of mammals.
Article in Genome biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 141 citations in OpenAlex.
- Bioaccumulation of Heavy Metals (17 Elements) in the Liver and Kidneys of the Least Weasel (Toxics · 2026Article
- Sodium Selenite Prevents Matrine-Induced Nephrotoxicity by Suppressing Ferroptosis via the GSH-GPX4 Antioxidant System.Biological trace element research · 2024Article
- Insights into Salinity Tolerance in Wheat.Genes · 2024Review
- A screening for optimal selenium enrichment additives for selenium-enriched fish production: Application of a HPLC-ICP-MS method.Food chemistry: X · 2024Article
- "Alphabet" Selenoproteins: Their Characteristics and Physiological Roles.International journal of molecular sciences · 2023Review
- Instigating prevalent abiotic stress resilience in crop by exogenous application of phytohormones and nutrient.Frontiers in plant science · 2023Review
- Plant Nutrition: An Effective Way to Alleviate Abiotic Stress in Agricultural Crops.International journal of molecular sciences · 2022Review
- Characterization and Quantification of Selenoprotein P: Challenges to Mass Spectrometry.International journal of molecular sciences · 2021Review
- Programmed Deviations of Ribosomes From Standard Decoding in Archaea.Frontiers in microbiology · 2021Review
- Bioinformatics of Selenoproteins.Antioxidants & redox signaling · 2020Review
- Bioinformatics of Metalloproteins and Metalloproteomes.Molecules (Basel, Switzerland) · 2020Review
- Article
- Deimination Protein Profiles inFrontiers in immunology · 2020Article
- Processive Recoding and Metazoan Evolution of Selenoprotein P: Up to 132 UGAs in Molluscs.Journal of molecular biology · 2019Article
- Selenium Deficiency Is Associated with Pro-longevity Mechanisms.Cell reports · 2019Article
- Sodium Selenate Treatment Using a Combination of Seed Priming and Foliar Spray Alleviates Salinity Stress in Rice.Frontiers in plant science · 2019Article
- Environmental Selenium and Human Health: an Update.Current environmental health reports · 2018Review
- Evolution, regulation, and function of porcine selenogenome.Free radical biology & medicine · 2018Review
- Challenges of site-specific selenocysteine incorporation into proteins by Escherichia coli.RNA biology · 2018Review
- Multiple RNA structures affect translation initiation and UGA redefinition efficiency during synthesis of selenoprotein P.Nucleic acids research · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSelenium (Se) is an essential trace element that occurs in proteins in the form of selenocysteine (Sec). It is transported throughout the body in the form of Sec residues in Selenoprotein P (SelP), a plasma protein of unclear origin recently proposed as an experimental marker of dietary Se status.
resultsHere, we report that the amino-terminal domain of SelP is distantly related to ancestral bacterial thiol oxidoreductases of the thioredoxin superfamily, and that its carboxy-terminal Se transport domain may have originated in early metazoan evolution by de novo accumulation of Sec residues. Reconstruction of evolutionary changes in the Se transport domain indicates a decrease in Sec content of SelP specifically in the mammalian lineage via replacement of Sec with cysteine (Cys). Sec content of mammalian SelPs varies more than two-fold and is lowest in rodents and primates. Compared to mammals, fish show higher Sec content of SelP, larger selenoproteomes, elevated SelP gene expression, and higher levels of tissue Se. In addition, mammals replaced Sec with Cys in several proteins and lost several selenoproteins altogether, whereas such events are not found in fish.
conclusionThese data suggest that evolution from fish to mammals was accompanied by decreased use of Sec and that analyses of SelP, selenoproteomes and Sec/Cys transitions provide a genetic marker of utilization of this trace element in vertebrates. The evolved reduced reliance on Se raises questions regarding the need to maximize selenoprotein expression by Se dietary supplements in situations when pathology is not imminent, a currently accepted practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.